| 临床结局观察性研究中的领先时间偏倚及控制 |
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| 引用本文： | 张娜,刘慧鑫,康殿民,汪宁.临床结局观察性研究中的领先时间偏倚及控制[J].中华流行病学杂志,2018,39(5):700-703. |
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| 作者姓名： | 张娜 刘慧鑫 康殿民 汪宁 |
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| 作者单位： | 102206 北京, 中国疾病预防控制中心性病艾滋病预防控制中心;250014 济南, 山东省疾病预防控制中心艾滋病防制所,100044 北京大学人民医院,250014 济南, 山东省疾病预防控制中心艾滋病防制所,102206 北京, 中国疾病预防控制中心性病艾滋病预防控制中心 |
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| 基金项目： | 山东省自然科学基金青年基金（ZR2014HQ038）；国家自然科学基金（81602939） |
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| 摘 要： | 临床结局观察性研究中可能存在领先时间偏倚。本文以筛检诊断试验对肿瘤患者生存时间的影响研究、高效抗反转录病毒治疗对HIV/AIDS生存时间的影响研究，两个实例阐述领先时间偏倚的概念、产生原因及控制，为准确分析评价检测、治疗等干预措施对存在多个疾病病程或分期疾病的作用效果时提供控制该偏倚的思路和方法。
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| 关 键 词： | 观察性研究 领先时间偏倚 控制 高效抗反转录病毒治疗 临床结局 |
| 收稿时间： | 2017/10/10 0:00:00 |
Lead time bias and its control in observational studies for clinical outcomes |
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| Zhang N,Liu Huixin,Kang Dianmin and Wang Ning.Lead time bias and its control in observational studies for clinical outcomes[J].Chinese Journal of Epidemiology,2018,39(5):700-703. |
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| Authors: | Zhang N Liu Huixin Kang Dianmin and Wang Ning |
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| Institution: | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China,Peking University People''s Hospital, Beijing 100044, China,Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China and National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China |
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| Abstract: | Lead time bias might exist in observational study for clinical outcomes. This paper summarizes the concept of lead time bias, causes and control of lead time bias by using the studies of influences of screening diagnostic test on cancer patients''survival and highly active antiretroviral therapy on HIV/AIDS patients'' survival as examples for the purpose of providing thinking and methods in the control of lead time bias for the accurate evaluation of the effects of interventions, such as test and treatment, on the diseases with multi courses or phases. |
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| Keywords: | Observational study Lead time bias Control Highly active antiretroviral therapy Clinical outcome |
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