胃癌及癌前状态MG7表达的动态观察及分析

目的：探讨在胃癌发生发展过程中MG7抗原表达的动态变化及意义。方法：采用免疫组化技术及组化技术检测406例胃黏膜MG7抗原的表达情况及肠上皮化生类型。结果：从组织学角度观察，正常胃黏膜→肠上皮化生及异型增生→胃癌；Ⅰ、Ⅱ型肠上皮化生→Ⅲ型肠上皮化生，MG7抗原阳性表达率依次上升(P＜0．01)。从临床疾病角度观察，浅表性胃炎→萎缩性胃炎→胃癌，MG7抗原阳性表达率依次上升(P＜0．01)。结论：MG7抗原与胃癌发生发展有良好的相关性，对胃癌具有较高的特异性；对萎缩性胃炎，Ⅲ型肠上皮化生与异型增生进行严密监测有可能提高早期胃癌的检出率，MG7在胃癌前疾病动态随访中具有重要应用价值。

Dynamic expression of antigen MG7 in the gastric cancer and gastric precancerous lesions

OBJECTIVE: To study the kinetics of MG7 expression in the process of gastric cancer development. METHODS: The expression level of antigen MG7 on gastric mucosa in 406 cases was determined by immunohistochemical techniques. The classification of intestinal metaplasia of gastric mucosa was determined by histochemistry techniques on gastric mucosa in 82 cases. RESULTS: The positive rates of MG7 expression in normal gastric mucosa, intestinal metaplasia and dysplasia of gastric mucosa and gastric cancer all increased gradually (P < 0.01). The positive rates of MG7 expression in superficial gastritis, atrophic gastritis and gastric cancer increased in sequence (P < 0.01). The positive rate of antigen MG7 expression in III intestinal metaplasia of gastric mucosa was significantly different with I and II intestinal metaplasia (P < 0.05). CONCLUSIONS: MG7 was quite specific in gastric cancer thus could be used as a good index in the screening of gastric cancer. Patients with III intestinal metaplasia of gastric mucosa, atrophic gastritis and dysplasia of gastric mucosa should be closely followed in order to improve the early detection on gastric cancer. It seemed that MG7 was clinically valuable in the dynamic follow-up of gastric precursors.