深圳市不同职业妇女人乳头瘤病毒感染现状及子宫颈上皮内瘤变现患率

目的了解深圳市不同职业妇女人乳头瘤病毒（HPV）感染现状及其子宫颈上皮内瘤变（CIN）现患率。方法调查深圳市5种职业人群的HPV感染现状及CIN现患率，其中中小学教师130人、外来劳务工385人、服务业从业人员316人、特困下岗职工199人、医务人员420人，并以自然人群——某社区居民595人为对照，共计调查2045名妇女。采用hc2法检测高危型HPV（HPV·HR），联合超柏氏薄层液基细胞学（LCT）进行子宫颈癌与癌前病变的筛查，凡筛查HR．HPV阳性并LCT≥ASCUS及／或LCT≥LSIL，均经阴道镜下活检病理检查确诊CIN。结果（1）不同职业妇女HR．HPV感染率不同，服务业从业人员感染率最高（19．3％），医务人员的感染率最低（11．9％），服务业从业人员感染率明显高于医务人员、外来劳务工及居民，差异有统计学意义（P〈0．05）。（2）在2045例妇女中，共发现HPV感染所致子宫颈病变199例，其中组织学可见HPV感染改变、CINl-3及子宫颈癌的发病率分别为4．11％、3．28％、1．67％、0．54％和0．15％，随着子宫颈病变程度的加重，其发病率逐渐降低。（3）不同职业妇女的不同程度CIN现患率明显不同，服务业从业人员HSIL发病率最高，而中小学教师的HSIL发病率最低。结论深圳市不同职业人群的HR·HPV感染率及CIN现患率不同。服务业从业人员的HR·HPV感染率及HSIL发病率最高。

Human papillomavirus infection and cervical intraepithelial neoplasia morbidity of women from different occupations in Shenzhen city, China

OBJECTIVE: To investigate the human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) morbidity of women from different occupations in Shenzhen city. METHODS: 2045 women of five kinds of occupation in Shenzhen city, including 130 teachers, 385 workers, 316 service women, 199 poverish women, 420 doctors or nurses and 595 general residents were included. We screened these women by methods of detecting high risk HPV of hc2 combing with LCT. Women with screening positive results were diagnosed CIN by colposcopic biopsy. RESULTS: (1) High risk factors on HPV infection rate in different occupations were different with the highest in service occupation (19.3%) while the lowest appeared in medical workers (11.9%). (2) In those 2045 women, we found 199 cervical lesions including pathological HPV infection, CIN1, 2, 3 and cervical cancers, with morbidity rates as 4.11%, 3.28%, 1.67%, 0.54% and 0.15% respectively. Along with the progress of the cervical lesions, the morbidity decreased. (3) The morbidity rates of CIN in different occupations were different, with the highest of HSIL in service occupation and the lowest in teachers. CONCLUSION: Women of different occupations in Shenzhen city had different high risk HPV infection rates and CIN morbidity. The HPV infection rate and HSIL morbidity were highest among women having service related jobs.