| 吸附精制百白破混合制剂两针接种的血清学效果免疫持久性观察 |
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| 引用本文： | 谢广中,刁连东,王树巧,周立,金志宽,黄浦泉,周生华,李金营,李明娟,何洪江.吸附精制百白破混合制剂两针接种的血清学效果免疫持久性观察[J].中华流行病学杂志,1987,8(3):139-143. |
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| 作者姓名： | 谢广中 刁连东 王树巧 周立 金志宽 黄浦泉 周生华 李金营 李明娟 何洪江 |
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| 作者单位： | 卫生部上海生物制品研究所;江苏省东海县卫生防疫站;江苏省卫生防疫站;原徐州地区卫生防疫站 |
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| 摘 要： | 预防百日咳、白喉、破伤风的方法是注射百白破混合制剂,共注射三针,吸附制剂注射两针,每针间隔一个月。于1978~1984年在江苏省东海县应用吸附精制百白破混合制剂进行两针注射观察。经血清学效果测定表明:白喉、破伤风、百日咳三种抗体均显著上升,且达到保护水平以上,百日咳抗体仅能维持六个月左右,一年后大多数低于保护水平,但经加强免疫后又能达到保护水平以上。基免三年至五年结果表明,两针免疫后白喉和破伤风可产生满意的血清学效果,百日咳抗体水平上升尚可。
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Observation of the Serological Effect and Immune Resistance of Two-dose Immunization with Adsorbed DTP |
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| Xie Guangzhong.Observation of the Serological Effect and Immune Resistance of Two-dose Immunization with Adsorbed DTP[J].Chinese Journal of Epidemiology,1987,8(3):139-143. |
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| Authors: | Xie Guangzhong |
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| Institution: | Shanghai Institute of Biological Products etc. |
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| Abstract: | The effective control of diphtheria, tetanus and pertussis is through active immunization with three-dose of combined DTP and two-dose of adsorbed DTP, at one month interval. During 1978~1984, investigation on the effect of two-dose immunization with adsorbed DTP was carried out in Donghai County of Jiangsu Provice. Serological results showed that the protection level against diphtheria, tetanus and pertussis was obtained. Although the level of the pertussis antibody was below the protection level one year later, it would exceed several times after giving a booster dose. The results of 3-5 year observation on primary immunization showed that two-dose immunization could give a satisfactory serological results for diphtheria and tetanus and an increased antibody level for pertussis. |
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