血管紧张素原基因多态性与原发性高血压关系的研究

目的 探索血管紧张素原（ＡＧＴ）的Ｍ２３５Ｔ多态性与上海市嘉定区望新乡原发性高血压的关系。方法 以人群为基础进行高血压病例－对照研究，应用ＰＣＲ－ＲＦＬＰ技术，分析ＡＧＴ的Ｍ２３５Ｔ多态性。结果 望新乡高血压病例组中ＡＧＴ基因ＴＴ基因型频率显著高于对照组，分别为４２．８％和３３．０％。相对于ＭＭ基因型，暴露于ＴＴ基因型的ＯＲ值为３．６１。病例组中Ｔ等位基因的频率也显著高于对照组，分别为７３．８９％

The relationship between polymorphism of angiotensinogen gene and essential hypertension

Objective To study the renin angiotensin system (RAS) involvement in the hormonal regulation of BP and blood volume and the relationship between angiotensinogen (AGT) was the sole preliminary acting materials in the RAS. Method Population based case control study was conducted using PCR RFLP techniques to explore the relationship between the M235T polymorphism of AGT and EH in Wangxin township, Jiading District of Shanghai. Results The frequency of TT genotype in EH cases was significantly higher than in controls ( 42.8 % and 33.0 %). The odds ratio ( OR ) for those exposed to TT genotype was 3.61 , comparing with MM genotype. It was suggested that TT genotype be the susceptible genotype of EH in Wangxin. The frequency of allele T in EH cases was 73.89%, significantly higher than that of 60.31% in controls. With the increase of allele T, the risk of EH also increased ( P < 0.05 ). In EH cases, the BMI increased in the order of MM, MT and TT, and significant differences between the groups were observed. Conclusion TT genotype is the susceptible genotype of EH in Wangxin.