| 一线培美曲塞联合艾迪注射液治疗老年晚期肺腺癌的临床观察 |
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| 引用本文： | 潘士勇,许德兵,史兆荣,王峻.一线培美曲塞联合艾迪注射液治疗老年晚期肺腺癌的临床观察[J].解放军保健医学杂志,2011(1). |
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| 作者姓名： | 潘士勇 许德兵 史兆荣 王峻 |
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| 作者单位： | 南京军区总医院干部保健科;江苏省省级机关医院; |
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| 基金项目： | 江苏省卫生厅科技发展课题基金(H201024) |
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| 摘 要： | 目的比较一线培美曲塞和培美曲塞联合艾迪注射液治疗老年晚期肺腺癌患者的疗效和不良反应。方法老年晚期肺腺癌患者共61例,随机分为治疗组和对照组。治疗组31例,培美曲塞500mg/m2,第1天静脉滴注,每3～4周为1个周期;艾迪50ml,静脉滴注,共15d;对照组30例,单药培美曲塞500mg/m2,第1天静脉滴注,3～4周为1个疗程。结果治疗组和对照组有效率(RR)分别为45.2%、43.3%,肿瘤控制率(TGCR)分别为71.0%、66.7%。两组不良反应均可耐受,治疗组耐受性及生存质量均高于对照组(P<0.05)。结论老年晚期肺腺癌患者可从单药一线培美曲塞中获益;培美曲塞联合艾迪注射液可减轻化疗相关不良反应,改善患者的生存质量。
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| 关 键 词： | 肺腺癌 培美曲塞 艾迪注射液 老年人 |
Clinical observation of pemetrexed or pemetrexed combined with aidi injection as first-line treatment of advanced lung adenocarcinoma for elderly patients |
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| PAN Shi-yong,XU De-bing,SHI Zhao-rong,et al.Clinical observation of pemetrexed or pemetrexed combined with aidi injection as first-line treatment of advanced lung adenocarcinoma for elderly patients[J].Journal Of Health Care And Medicine in Chinese Pla,2011(1). |
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| Authors: | PAN Shi-yong XU De-bing SHI Zhao-rong |
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| Institution: | PAN Shi-yong,XU De-bing,SHI Zhao-rong,et al(Department of Geriatrics,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,China) |
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| Abstract: | Objective To observe the efficacy and toxic reaction of pemetrexed or pemetrexed combined with Aidi injection as first-line treatment of advanced lung adenocarcinoma for elderly patients.Methods Sixty-one elderly patients with advanced lung adenocarcinoma were divided into treatment and control groups randomly.In treatment group,31 cases received pemetrexed at a dose of 500 mg/m2 on days 1,repeated every 3-4 weeks for one recycles;in the same time of pemetreaed chemotherapy,Aidi injection(50 ml)was given in... |
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| Keywords: | Lung adenocarcinoma Pemetrexed Aidi injection Elderly patients |
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