噻托溴铵联合布地奈德福莫特罗粉吸入剂治疗COPD加重期的临床疗效

目的分析噻托溴铵粉吸入剂联合布地奈德福莫特罗粉吸入剂治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期的临床疗效。方法选择我院COPD急性加重期患者共70例,数字表法随机分两组,每组35例,对照组的患者给予布地奈德福莫特罗粉吸入剂治疗,观察组在该基础上增加噻托溴铵粉吸入剂。比较两组住院时间、治疗前后患者肺功能指标、血气分析结果、C反应蛋白、总有效率。结果观察组住院时间短于对照组,肺功能一秒末用力呼气容积、最高呼气流量、第一秒用力呼气容积/肺活量高于对照组,治疗后患者血气分析改善、C反应蛋白低于对照组,总有效率高于对照组,P<0.05。结论布地奈德福莫特罗粉吸入剂联合噻托溴铵粉吸入剂对于COPD急性加重期的治疗效果确切。

Tiotropium Bromide Combined With Budesonide and Formoterol Fumarate Powder for Inhalation in the Treatment of COPD Exacerbation

Objective TO analyze the clinical efficacy of tiotropium bromide powder inhalation combined with budesonide and formoterol in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods 70 patients with acute exacerbation of COPD in our hospital were randomly divided into two groups with 35 cases in each group.The patients in the control group were treated with budesonide and formoterol powder inhalation,and the observation group was given tiotropium bromide powder inhalation on the basis of the treatment.The hospitalization time,pulmonary function indexes,blood gas analysis results,C-reactive protein and total effective rate were compared between the two groups.Results The hospitalization time of the observation group was shorter than that of the control group,the forced expiratory volume at the end of one second,the maximum expiratory flow,forced expiratory volume/vital capacity in the first second were higher than those in the control group.After treatment,the blood gas analysis was improved,C-reactive protein was lower than that of the control group,and the total effective rate was higher than that of the control group,P<0.05.Conclusion Budesonide and formoterol powder inhalation combined with tiotropium bromide powder inhalation is effective in the treatment of acute exacerbation of COPD.