氟化物的抗雄激素样作用研究

目的研究氟化物的抗雄激素样作用,并探讨其生殖系统损伤机制。方法采用Hershberger实验方法;同时应用放射免疫法检测血清睾酮含量。结果染毒组雄激素依赖组织（精液囊和凝集腺、前列腺、肛提肌/球海绵体肌、阴茎头、尿道球腺、阴茎）脏器系数及血清睾酮含量均高于阳性对照组和空白对照组,差异有统计学意义（P〈0.05）;染毒组雄激素依赖组织脏器系数与阴性对照组相比,差异无统计学意义（P〉0.05）。低剂量染毒组血清睾酮含量高于阴性对照组,差异有统计学意义（P〈0.05）,中剂量和高剂量染毒组血清睾酮与阴性对照组相比,差异无统计学意义（P〉0.05）;各处理组之间肝、脾、肾、肾上腺脏器系数差异均无统计学意义（P〉0.05）。结论氟化钠可能不具有抗雄激素样作用。

The Experimental Study on the Anti - androgen effect of Fluoride

Objective To study the anti-androgen effect of fluoride,and approach the damage mechanism on the reproductive system.Methods Use the method of rat Hershberger Assay;and detect the level of blood serum testosterone by radio-immunity.Results The weight percentage of androgen related organs(seminal vesicle,prostate,LA/BC muscle,glans penis,Cowper's gland,penis)of NaF treated groups and the level of blood serum testosterone is higher than the positive control group and blank control group,the deficiencies were significant(P<0.05);There is essentially no differences in the indexes of weight percentage of androgen related organs between NaF treated groups and negative control group(P>0.05),the blood serum testosterone of low dose of NaF treated group is higher than the negative control group,the deficiencies were significant(P<0.05),and there are essentially no differences in the blood serum testosterone between middle and high dose NaF treated groups and negative control group;There have no significant deficiencies among the treatment groups' organs such as lives,spleens,kidneys and adrenal glands(P>0.05).Conclusions Sodium Fluoride may not have the anti-androgen activity.