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洛阳市肝炎病毒感染与肝癌的血清流行病学研究
引用本文:王启敏,张竹梅,边建超,汤伯明,王其军,朱鑫,樊巍巍,曹燕燕.洛阳市肝炎病毒感染与肝癌的血清流行病学研究[J].河南预防医学杂志,2004,15(4):197-199.
作者姓名:王启敏  张竹梅  边建超  汤伯明  王其军  朱鑫  樊巍巍  曹燕燕
作者单位:1. 洛阳市卫生防疫站,河南,洛阳,471000
2. 复旦大学公共卫生学院,上海,200032
基金项目:国家自然科学基金 (39870 6 5 4 )
摘    要:目的 探讨洛阳市HBV、HCV和HGV感染与肝癌的关系。方法 收集洛阳市 6 8例肝癌患者和 179例对照的血清 ,应用EIA法检测HBV、HCV和HGV感染指标。结果 HBV感染的六项血清学指标在病例组和对照组的差异有统计学意义 ,抗 -HCV在两组的差异也具有统计学意义 ,而所有研究对象均未检测到抗 -HGV。HBV与HCV合并感染在肝癌的发生中呈简单相加模式。HBsAg、总HBV感染和抗 -HCV分别可以解释洛阳市肝癌病因的 84 .78%、6 1.19%和 6 .2 0 % ,而抗 -HBs阳性则使肝癌发病危险降低 32 .75 %。结论 HBV和HCV感染是洛阳市肝癌的主要危险因素。

关 键 词:肝癌:HBV  HCV  HGV
文章编号:1006-8414(2004)04-0197-03
修稿时间:2004年4月12日

Seroepidemiological studies on the relationship between hepatitis B,C and G viral infections and hepatocellular carcinoma in Luoyang,China.
WANG Qi-Min,ZHANG Zhu-Mei,BIAN Jian-Chao,et al..Seroepidemiological studies on the relationship between hepatitis B,C and G viral infections and hepatocellular carcinoma in Luoyang,China.[J].Henan Journal of Preventive Medicine,2004,15(4):197-199.
Authors:WANG Qi-Min  ZHANG Zhu-Mei  BIAN Jian-Chao  
Abstract:Objective: To relationship between HBV,HCV and HGV infection and hepatocelluar carcinoma (HCC) in Luoyang. Methods: Collected 68 in-patients with HCC as case group and 179 non-1iver disease,non-tumor people aS control group.Then detected their the infective markers of HBV,HCV and HGV using EIA.Results: Frequencies of six HBV infection markers between cases and controls were all.Frequencies of anti-HCV in cases and controls were statisticallv signjficant too.But the marker of HGV infection was not detected in two groups.Co-infection of HBV and HCV showed Simple additive effectS in hepatocarcinogenesis.In the risk factors of HCC in Luoyang,HBsAg,omni-HBV infection and anti-HCV could count For 84.78%,61.19% and 6.20%,respectivelv.While anti-HBs(+) could make the riSk of HCC decrease 32.75%.Conclution: HBV and HCV infections were the main risk factorS of HCC in Luoyang.
Keywords:hepatocellular carcinoma  HBV  HCV  HGV
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