慢性炎症与多囊卵巢综合征的关系及相关研究进展

多囊卵巢综合征（PCOS）是发生于青春期或育龄期女性常见的内分泌失调性疾病，以排卵障碍、胰岛素抵抗（IR）和高雄激素血症（HA）为主要特征，是女性不孕症的主要原因之一。慢性炎症是机体发挥防御功能的重要途径之一，但也是代谢性疾病形成的原因之一。PCOS患者存在低度的慢性炎症，某些重要炎症因子的分泌水平异常升高，提示慢性炎症与PCOS发生、发展之间可能具有相关性，但尚存争议。已有研究表明，PCOS病理过程中释放一些炎症因子，引发慢性低度炎症。新近报道指出，慢性炎症可能在PCOS早期即参与了肥胖、IR和HA的发生；将某些具有抗炎功用的药物应用于PCOS患者，改善其炎性微环境，具有肯定的疗效。本文综述慢性炎症与PCOS的关系及相关研究进展。

Chronic Inflammation in Pathogenesis of Polycystic Ovary Syndrome and Research Progress

Polycystic ovary syndromes (PCOS), a common endocrine disorder in women of puberty and childbearing age, is characterized by ovulation disorder, insulin resistance (IR) and hyperandrogenemia (HA). It is one of the main causes of female infertility. Chronic inflammation is an important way of defense for the body. However, it is also one of the causes of metabolic diseases. Patients with PCOS have chronic and low-grade inflammation, because the levels of some inflammatory factors were abnormally increased in those patients. More and more evidences have suggested the close relationship between chronic inflammation and the pathogenesis of PCOS, although there is still some controversy. Many inflammatory factors were secreted during the pathophysiological duration of PCOS, which causes the chronic low-grade inflammation. New evidences suggested that chronic inflammation may be actually involved in obese, IR and HA in the early stage of PCOS. Some anti-inflammatory drugs have been used to improve the inflammatory microenvironment of PCOS in the clinical practice, with a definite effect. In this paper, the relationship between chronic inflammation and the pathogenesis of PCOS, as well as the research progress was reviewed.