长乐地区居民血清胃蛋白酶原和幽门螺杆菌抗体水平分析

目的]分析长乐地区居民血清胃蛋白酶原（PG）含量和幽门螺杆菌（Hp）感染率,了解基本人群分布特征,探索相关影响因素。方法]用ELISA法检测224名居民血清PGⅠ、PGⅡ含量,并计算PGⅠ/Ⅱ比值;用ELISA法检测血清Hp IgG抗体水平。结果]长乐地区居民血清PGⅠ、PGⅡ及PGⅠ/Ⅱ中位值分别为110.8μg/L、13.9μg/L、7.9,在不同性别、不同年龄组中3者类似。Hp感染率为49.6%,感染者血清PGⅡ值（中位数为15.8μg/L）高于非感染者（11.6μg/L,P〈0.01）,但PGⅠ/Ⅱ比值（7.3）较后者低（8.5,P=0.023）。结论]长乐地区居民血清PG水平呈明显偏态分布,与Hp感染密切相关,是否受性别、年龄影响有待进一步研究。

Analysis on Serum Pepsinogen and Helicobacter Pylori IgG in the Residents of Changle City,Fujian

Objective] To analyze the serum concentrations of pepsinogen （PG） and helicobacter pylori （Hp） IgG in the residents of Changle city,Fujian,and analyze the characteristics of the distribution and the related factors. Methods] The serum concentrations of PG Ⅰ ,PG Ⅱ and Hp IgG were determined by using ELISA method. Results] The median of PG Ⅰ ,PGⅡ and PG Ⅰ / Ⅱ were 110.8 μg/L,13. 9 μg/L and 7.9 respectively,and they were not significantly different between male and female or among age groups. The positive rate of Hp infection was 49.6%. The PG Ⅱ concentration of Hp infection （median： 15.8 μg/L） was significantly higher than that without Hp infection （median= 11.6 μg/L,P〈0.01）,but the ratio of PG Ⅰ/Ⅱ（7.3） was significantly lower than that of the latter （8.5, P = 0. 023）. Conclusion] The serum concentrations of PG in the residents of Changle city show skew distribution,and they are related with Hp infection. It is necessary to perform further studies in order to confirm whether the concentrations of PG are affected by gender and age or not.