蔬菜水果摄入与前列腺癌风险的Meta分析

目的系统评价蔬菜水果摄入与前列腺癌(prostate cancer,PCa)风险之间的关系,为前列腺癌的预防策略提供相关依据。方法计算机检索Pubmed、Embase、Web of science数据库,查找评价蔬菜和/或水果摄入与前列腺癌风险之间关系的队列研究以及相关文献,对纳入的文献进行质量评级,采用R软件(4.0.3版本)进行Meta分析。结果共纳入20篇队列研究,4项研究仅报道了水果摄入与前列腺癌风险的关联,4项研究仅报道了蔬菜摄入与前列腺癌的风险的关系,12项研究同时报道了水果与蔬菜摄入与前列腺癌风险。Meta分析结果提示,高摄入组经膳食摄入蔬菜虽然存在降低前列腺癌发生风险的现象,然而其差异并不存在统计显著性(RR=0.97;95%CI:0.94~1.01,P=0.11;I²=21.3%,P=0.21)。水果摄入与前列腺癌的风险不存在显著相关性(RR=1.00;95%CI:0.96~1.04,P=0.99)。结论蔬菜和/或水果的摄入与前列腺癌风险不存在显著相关性。

Meta-analysis of the relationship between the intake of fruits and vegetables and the risk of prostate cancer

Objective To systematically evaluate the relationship between the intake of fruits and vegetables and the risk of prostate cancer,so as to provide relevant evidence for formulating the prevention strategies of prostate cancer.Methods Pubmed,Embase,and Web of Science databases were searched by computer for cohort studies and related literatures evaluating the relationship between vegetable and/or fruit intake and prostate cancer risk.The quality of the included literature was rated,and meta-analysis was carried out using R software(4.0.3 version).Results A total of 20 cohort studies were included.Four studies only reported the relationship between fruit intake and the risk of prostate cancer,4 studies only reported the relationship between vegetable intake and the risk of prostate cancer,and 12 studies reported the relationship between fruit and vegetable intake and the risk of prostate cancer.Meta-analysis results indicate that although dietary intake of vegetables in the high-intake group may reduce the risk of prostate cancer,the difference was not statistically significant(RR=0.97;95%CI:0.94-1.01,P=0.11);I²=21.3%,P=0.21.There was no significant correlation between fruit intake and the risk of prostate cancer(RR=1.00;95%CI:0.96-1.04,P=0.99).Conclusion There is no significant correlation between the intake of vegetables and/or fruits and the risk of prostate cancer.