糖代谢异常患者发生亚临床甲状腺功能减退症的临床特征及其相关因素

目的 分析糖代谢异常患者发生亚临床甲减的临床特征及其相关因素,为糖代谢异常者防治亚临床甲减提供理论依据.方法 选取2018年3月至2020年3月来天门市第一人民医院内分泌科进行治疗的糖代谢异常患者428例,抽取所有患者空腹肘静脉血5mL,采用全自动免疫分析系统测定血清FT3、FT4、TSH水平;采用全自动分析仪测定包括...

Clinical status and related factors of subclinical hypothyroidism in patients with abnormal glucose metabolism

Objective To analyze the clinical situation and related factors of subclinical hypothyroidism in patients with abnormal glucose metabolism,and to provide theoretical basis for the prevention and treatment of subclinical hypothyroidism in patients with abnormal glucose metabolism.Methods A total of 428 patients with abnormal glucose metabolism who were treated in the Department of Endocrinology of Tianmen First People′s Hospital from March 2018 to March 2020 were selected,and serum FT3,FT4 and TSH levels were determined by automatic immune analysis system.Automatic analyzer was used to measure the levels of FBG,HbA1c,TC,TG,LDL-C and UA.A self-made questionnaire was used to investigate the basic information of all subjects,including gender,age,abnormal course of glucose metabolism,BMI and blood pressure.The survey method was combined with telephone inquiry and field investigation.Logistic regression was used to analyze the independent risk factors for subhypothyroidism in patients with abnormal glucose metabolism.Results Among 428 patients with abnormal glucose metabolism,89 patients were accompanied by subclinical hypothyroidism,including 39 males and 43 females,with an average age of(45.12±8.13)years.The prevalence of subhypothyroidism in females was higher than that in males,and the difference was statistically significant(χ²=4.353,P<0.05).There was no significant difference in serum FT₃ and FT₄ levels between the two groups(P>0.05).The serum TSH level in experimental group was significantly higher than that in control group(P<0.05).Univariate analysis showed statistically significant differences in age,gender,abnormal course of glucose metabolism,BMI,BMI,FBG,HbA1c,UA,TC,LDL-C and SBP between the two groups(P<0.05).Logistic regression analysis showed that old age,high levels of FBG,TC,SBP and UA were independent risk factors for subclinical hypothyroidism in patients with abnormal glucose metabolism(P<0.05).Conclusion The incidence rate of patients with abnormal glucose metabolism complicated with subclinical hypothyroidism is high.The biochemical indexes such as blood glucose,blood lipid,blood pressure and uric acid should be monitored regularly.The early regulation of glucose metabolism disorder is an effective way to prevent and treat subclinical hypothyroidism.