饮酒与慢性阻塞性肺疾病风险关系的meta分析

目的 探讨饮酒与慢性阻塞性肺疾病风险(chronic obstructive pulmonary disease, COPD)的关系。 方法 计算机检索PubMed、Web of Science、Embase、中国知网、万方数据库和维普数据库,搜集各数据库建库至2021年11月公开发表的有关饮酒与COPD风险的观察性研究。由2位研究者根据文献纳入及排除标准独立筛选文献并提取数据。采用Stata 12.0软件进行统计学分析。 结果 共纳入8篇文献(2篇队列研究文献和6篇横断面研究文献),共纳入209 489例研究对象。meta分析结果显示,与最低饮酒量组相比,最高饮酒量组发生COPD的风险无显著变化(RR=0.97, 95%CI:0.87~1.08);与不饮酒组相比,少量或中度饮酒组发生COPD的风险降低(RR=0.87, 95%CI:0.81~0.94);与少量或中度饮酒组相比,过量饮酒组发生COPD的风险无显著变化(RR=1.26, 95%CI:0.98~1.63)。 结论 meta分析结果提示少量或中度饮酒可降低COPD的风险。过量饮酒是否会增加COPD的风险尚需进一步研究。

Meta-analysis on the relationship between alcohol intake and the risk of chronic obstructive pulmonary disease

Objective To explore the association between alcohol intake and the risk of chronic obstructive pulmonary disease (COPD). Methods PubMed, Web of Science, Embase, CNKI, Wanfang database, and Weipu database were searched online to collect observational studies on alcohol intake and the risk of COPD published from the establishment of each database through November 2021. Two researchers independently screened the literature according to the inclusion and exclusion criteria and then extracted the data. Statistical analyses were performed using Stata 12.0 software. Results A total of 8 articles (2 cohort and 6cross-sectional studies) were included, and 209,489 participants were pooled into this meta-analysis. Results of this meta-analysis showed that there was no significant change in COPD risk in the group with the highest alcohol intake (RR=0.97, 95%CI:0.87-1.08) compared with that in the group with the lowest alcohol intake. The group with light or moderate alcohol intake had a lower risk of COPD (RR=0.87, 95%CI:0.81-0.94) compared with the group without drinking. No significant change was found in COPD risk in the group with excessive alcohol intake (RR=1.26, 95%CI:0.98-1.63) compared with the group with light or moderate alcohol intake. Conclusion Results of this meta-analysis suggest that light or moderate alcohol intake may reduce the risk of COPD. And further studies are needed to analyze whether excessive alcohol intake can increase the risk of COPD.