| HIV-1 CRF55_01B毒株流行特征的研究进展 |
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| 引用本文： | 梁淑家,辛若雷. HIV-1 CRF55_01B毒株流行特征的研究进展[J]. 实用预防医学, 2022, 29(6): 766-769. DOI: 10.3969/j.issn.1006-3110.2022.06.030 |
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| 作者姓名： | 梁淑家 辛若雷 |
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| 作者单位： | 1.广西壮族自治区疾病预防控制中心,广西重大传染病防控与生物安全应急响应重点实验室(21-220-12),广西 南宁 530028;2.北京市疾病预防控制中心,北京 100013 |
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| 基金项目： | “十三五”国家科技重大专项(2018ZX10715008);北京市自然科学基金面向项目(7202074) |
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| 摘 要： | CRF55_01B是我国报道的HIV-1主要流行毒株之一,具有较为独特的流行病学和基因进化特征。近几年HIV-1分子流行病学监测发现CRF55_01B已经成为我国第五个主要流行HIV-1毒株。本研究从他的发现起源、流行情况、致病性和耐药性及参与的重组等方面进行综述,并讨论了与其流行密切相关的社会和生物学因素。
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| 关 键 词： | HIV-1 CRF55_01B重组毒株 流行特征 流行重组型 |
| 收稿时间： | 2022-01-10 |
Research progress on the epidemic characteristics of HIV-1 CRF55_01B |
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| LIANG Shu-jia,XIN Ruo-lei. Research progress on the epidemic characteristics of HIV-1 CRF55_01B[J]. Practical Preventive Medicine, 2022, 29(6): 766-769. DOI: 10.3969/j.issn.1006-3110.2022.06.030 |
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| Authors: | LIANG Shu-jia XIN Ruo-lei |
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| Affiliation: | 1. Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response (21-220-12), Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning, Guangxi 530028, China;2. Beijing Center for Disease Prevention and Control, Beijing 100013, China |
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| Abstract: | With unique epidemiology and genetic evolution characteristics, CRF55_01B has become one of the major epidemic strains of HIV-1 in published public reports in China. Recent HIV-1 molecular epidemiology surveillance indicates thatCRF55_01B has become the fifth major HIV-1 strain in China. In this paper, characters like the origin of its discovery,prevalence, pathogenicity, drug resistance and involved recombination have been described in detail. In addition, the possible factors of sociology and biology closely associated with the prevalence of CRF55_01B are also discussed. |
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| Keywords: | HIV-1 CRF55_01B recombinant strain epidemic characteristic circulating recombinant form |
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