| 卡介苗多糖核酸微乳的研究 |
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| 引用本文： | 丁燕飞,姚瑶,姜素芳,陶昱斐.卡介苗多糖核酸微乳的研究[J].实用预防医学,2006,13(1):173-175. |
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| 作者姓名： | 丁燕飞 姚瑶 姜素芳 陶昱斐 |
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| 作者单位： | 1. 中南大学药学院,湖南,长沙,410013
2. 湖南师范大学医学院 |
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| 基金项目： | 中南大学药学院中青年教师科研基金 |
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| 摘 要： | 目的制备卡介苗多糖核酸(BCG-PSN)微乳。方法采用磷脂为乳化剂,乙醇为助乳化剂,油酸乙酯为油相,用改良三角相图法确定微乳区域,优化BCG-PSN微乳处方组成。结果与结论所制得BCG-PSN微乳澄清透明,性质稳定。
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| 关 键 词： | 卡介苗多糖核酸 微乳 磷脂 油酸乙酯 |
| 文章编号： | 1006-3110（2006）01-0173-03 |
| 收稿时间： | 2005-09-13 |
| 修稿时间： | 2005年9月13日 |
Study on Preparation BCG - PSN Microemulsion |
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| DING Yan - fei , YAO Yao, JIANG Su - fang ,et al..Study on Preparation BCG - PSN Microemulsion[J].Practical Preventive Medicine,2006,13(1):173-175. |
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| Authors: | DING Yan - fei YAO Yao JIANG Su - fang |
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| Institution: | 1. School of Pharmaceutical Sciences of Central South University, Changsha 410013, Hunan ; 2. Medical College, Hunan Normal University, Changsha 410013, Hunan |
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| Abstract: | Objective To prepare polysaccharide nucleic acid fraction of bacillus Calmette-Guerin(BCG-PSN) microemulsion(ME). Method Lecithin was used as emulsifier,anhydrous alcohol as assistant emulsifier,ethyl oleate as the oil phase.The triangular phase diagrams were used to identify the area of W/O microemulsion.An optimized formulation had been established.Result and Conclusion The obtained BCG-PSN microemulsion has good appearance and stability. |
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| Keywords: | Polysaccharide nucleic acid fraction of bacillus Calmette-Guerin(BCG-PSN) Microemulsion Lecithin Ethyl oleate |
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