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乙型肝炎血源疫苗免疫后16~18年的长期免疫效果定群研究
引用本文:沈立萍,杨进业,李艳萍,莫兆军,方孔雄,韦少超,李荣成,董邕辉,张勇,毕胜利.乙型肝炎血源疫苗免疫后16~18年的长期免疫效果定群研究[J].实用预防医学,2006,13(6):1425-1427.
作者姓名:沈立萍  杨进业  李艳萍  莫兆军  方孔雄  韦少超  李荣成  董邕辉  张勇  毕胜利
作者单位:1. 广西壮族自治区疾病预防控制中心,广西,南宁,530021
2. 广西隆安县疾病预防控制中心
3. 中国疾病预防控制中心病毒病所
基金项目:广西壮族自治区卫生厅课题(基金合同号:Z2005111)
摘    要:目的 评价新生儿乙肝疫苗普种预防乙型肝炎病毒(HBV)感染的长期免疫效果,探讨乙肝血源疫苗免疫持久性.方法 出生队列定群研究结合横断面调查的方法,对象为1987-1989年出生并接种乙肝血源疫苗的人群,用固相放射免疫法(SPRIA)法检测HBV感染标志,结果与前期数据比较分析.结果 (1)1987-1989队列的免疫人群在免疫7年、14年、18年后的疫苗保护效果分别为89.7%,94.8%和87.8%,差别无统计学意义;保护性抗体水平分别为57.37%,32.80%,36.67%,免后14、18年的抗体保持在一致水平;(2)乙肝血源疫苗接种16~18年后,平均HBsAg阳性率为1.99%;保护性抗体水平为36.67%,总表面抗体阳性率为62.91%.结论 新生儿普种乙肝血源疫苗可有效预防HBV感染,疫苗免疫18年后保护效果稳定,不必进行人群加强免疫.

关 键 词:乙型肝炎血源疫苗  乙型肝炎病毒  表面抗原  表面抗体  远期效果
文章编号:1006-3110(2006)06-1425-03
修稿时间:2006年8月15日

Evaluation of Long-term Protective Efficacy of Infant Hepatitis B Plasma-derived Vaccine Immunization
SHEN Li-ping YANG Jin-ye LI Yan-ping.Evaluation of Long-term Protective Efficacy of Infant Hepatitis B Plasma-derived Vaccine Immunization[J].Practical Preventive Medicine,2006,13(6):1425-1427.
Authors:SHEN Li-ping YANG Jin-ye LI Yan-ping
Abstract:Objective To evaluate the long - term efficacy of newborns hepatitis B vaccine immunization.Methods By using birth-cohort combined with cross- sectional study to evaluate the three newborn cohorts of 1987- 1989 among those who had received hepatitis B vaccination.RIA and SPRIA were used to detect their HBV infectious signals and the re- sults were compared with the historical data.Results (1)After being immunized for 7,14,18 years the protective rates of 1987 - 1989 cohorts were 89.7%,94.8% and 8?.8% respectively,and there was no significant difference.The average positive rates of HBV protective antibody were 57.37 %,32.80 %,and 36.67 % respectively.The protective antibody of 14 and 18 years remained at the same level.(2)The average positive rate of HBV surface antigent was 1.99% 0 HBV protective antibody was 36.67%,and the total HBV surface antibody positive rate was 62.91%.Conclusions The universal new- born HB vaccination program has been proved to be effectively in controlling HBV infection.The protective efficacy of immu- nized people is stable.It is unnecessarily to carry out further HB reinforce immunization.
Keywords:Hepatitis B plasma-derived vaccine  HBV  Hepatitis B surface antigent(HBsAg)  Hepatitis B surface antibody(HBsAb)  Long-term effectiveness
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