胃癌的环境危险因素及其归因危险度分析

目的 分析胃癌的环境危险因素并进行归因危险度评价.方法 采用1:1配对病例对照研究方法,对南京地区121例原发性胃癌病例进行环境危险因素调查,综合评价环境危险因素在胃癌发生中的归因危险度.结果 多因素条件Logistic回归分析显示胃癌的发病与下列4种因素有关:吸烟、食用腌制食品、三餐不定时、消化系统疾病家族史;四因素的调整人群归因危险度ARc%依次为29.9%、24.3%、21.0%、9.46%,综合人群归因危险度sAR为54.7%.结论 在胃癌防治中,可将改变不良饮食习惯、戒除不良嗜好等作为重要的Ⅰ级预防对策.

Analysis on Attributable Risk for Environmental Risk Factors of Gastric Cancer

Objective To estimate the population attributable risk for environmental risk factors in the development of gastric cancer.Methods A case-controlled study was carried out for calculating ARc% for each environment risk factor in gastric cancer and sAR for all of the risk factors among the 121 cases of gastric cancer patients and controls in Nanjing area. Results Tobacco smoking,irregular meal time,pickled food,and family history of digestive system disease were the risk factors of gastric cancer(OR:2.1,1.6,1.7,and 8.4).ARc% in turn was 29.9%,24.3%,21.0%,and 9.64%.sAR accounted for 54.7%.The result suggested that environmental risk factors played cooperated roles in gastric cancer patho- genesis.Conclusion Preventive strategy should base on the environmental risk factors to prevent the development of gas- tric cancer.