噻托溴铵治疗慢性阻塞性肺病稳定期的临床观察

目的观察吸入噻托溴铵治疗慢性阻塞性肺病（COPD）稳定期的治疗效果。方法将60例稳定期COPD随机分成2组,治疗组给予噻托溴铵吸入,对照组给予常规治疗,比较两组治疗前后肺功能,6 min步行距离、急性加重次数和不良反应。结果治疗组肺功能明显好转,6 min步行距离明显改善（P〈0.05）,急性加重次数减少,无严重不良反应。结论噻托溴铵对于COPD稳定期安全有效。

Clinical Observation on Effect of Tiotropium Bromide on Patients with Stable Chronic Obstructive Pulmonary Disease

Objective To observe the clinical efficacy of inhaled tiotropium bromide in patients with chronic obstructive pulmonary disease in the stable phase.Methods Sixty patients with stable COPD were randomly divided into treatment group and control group.The patients in treatment group were received inhaled tiontropium bromide,while the patients in control group were given routine treatment.Before and after the treatment,lung function,6-minute walking distance,times of acute exacerbation and adverse reactions were compared between the two groups.Results As compared with control group,FEV1/FVC and FEV1(% predict) in treatment group were significantly increased,6-minute walking distance improved(P<0.05) and the times of acute exacerbation reduced.No significant adverse reaction was found during the treatment.Conclusions Inhaled tiotropium bromide is safe and effective for patient with stable COPD.