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混合线性模型在临床试验中重复测量资料的应用
引用本文:黄坤,倪宗瓒,程薇波. 混合线性模型在临床试验中重复测量资料的应用[J]. 现代预防医学, 2005, 32(11): 1584-1584,F0003
作者姓名:黄坤  倪宗瓒  程薇波
作者单位:四川大学公共卫生学院,成都,610041
摘    要:目的:探讨混合线性模型在临床试验重复测量资料分析中的应用。方法:利用混合线性模型分析结果指标为定量资料的重复测量资料,通过参数和标准误的估计得出统计学结论。结果:对于临床试验重复测量资料,混合线性模型能有效的考虑数据相关性,处理有缺失值的资料,可以获得组别、时间及有无交互作用的结论。结论:采用混合线性模型对临床试验重复测量资料进行统计分析,可以更客观的进行药物疗效评价。

关 键 词:混合线性模型 临床试验 重复测量资料
文章编号:1003-8507(2005)11-1584-02
收稿时间:2005-10-17
修稿时间:2005-10-17

MIXED LINEAR MODEL FOR THE REPEATED MEASURE DATA IN CLINICAL TRIALS
HUANG Kun,NI Zong-zan,CHENG Wei-bo. MIXED LINEAR MODEL FOR THE REPEATED MEASURE DATA IN CLINICAL TRIALS[J]. Modern Preventive Medicine, 2005, 32(11): 1584-1584,F0003
Authors:HUANG Kun  NI Zong-zan  CHENG Wei-bo
Affiliation:The Huaxi College of Public Health, Sichuan University , Chengdu , 610041
Abstract:Objective:To explore the application of the mixed linear model in the repeated measures data of clinical trials.Methods:The repeated measure data were analyzed with quantitative data by mixed linear Model and conclusions were drawn according to the parameter and standard error.Results:The method could effciently consider the intra-class correlation,advisably deal with the mising value,correctly obtain the estimate and standard error.Condusion:It can get more objective result of medicine effect by using Mixed linear Model in the repeated measures data of clinical trials.
Keywords:Mixed linear   Model clinical trials   Repeated measures data
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