| 混合线性模型在临床试验中重复测量资料的应用 |
| |
| 引用本文： | 黄坤,倪宗瓒,程薇波. 混合线性模型在临床试验中重复测量资料的应用[J]. 现代预防医学, 2005, 32(11): 1584-1584,F0003 |
| |
| 作者姓名： | 黄坤 倪宗瓒 程薇波 |
| |
| 作者单位： | 四川大学公共卫生学院,成都,610041 |
| |
| 摘 要： | 目的：探讨混合线性模型在临床试验重复测量资料分析中的应用。方法：利用混合线性模型分析结果指标为定量资料的重复测量资料，通过参数和标准误的估计得出统计学结论。结果：对于临床试验重复测量资料，混合线性模型能有效的考虑数据相关性，处理有缺失值的资料，可以获得组别、时间及有无交互作用的结论。结论：采用混合线性模型对临床试验重复测量资料进行统计分析，可以更客观的进行药物疗效评价。
|
| 关 键 词： | 混合线性模型 临床试验 重复测量资料 |
| 文章编号： | 1003-8507（2005）11-1584-02 |
| 收稿时间： | 2005-10-17 |
| 修稿时间： | 2005-10-17 |
MIXED LINEAR MODEL FOR THE REPEATED MEASURE DATA IN CLINICAL TRIALS |
| |
| HUANG Kun,NI Zong-zan,CHENG Wei-bo. MIXED LINEAR MODEL FOR THE REPEATED MEASURE DATA IN CLINICAL TRIALS[J]. Modern Preventive Medicine, 2005, 32(11): 1584-1584,F0003 |
| |
| Authors: | HUANG Kun NI Zong-zan CHENG Wei-bo |
| |
| Affiliation: | The Huaxi College of Public Health, Sichuan University , Chengdu , 610041 |
| |
| Abstract: | Objective:To explore the application of the mixed linear model in the repeated measures data of clinical trials.Methods:The repeated measure data were analyzed with quantitative data by mixed linear Model and conclusions were drawn according to the parameter and standard error.Results:The method could effciently consider the intra-class correlation,advisably deal with the mising value,correctly obtain the estimate and standard error.Condusion:It can get more objective result of medicine effect by using Mixed linear Model in the repeated measures data of clinical trials. |
| |
| Keywords: | Mixed linear Model clinical trials Repeated measures data |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
