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| TPH2基因单核苷酸多态性与单相抑郁症及其症状表型的关联研究 | |
| 引用本文： | 张玉琦,徐文炜,袁国桢,姚建军,程灶火,刘朝军,刘庆海,王爱荣,史桂芝,王宝恒,张长松,成义仁,李克.TPH2基因单核苷酸多态性与单相抑郁症及其症状表型的关联研究[J].现代预防医学,2011,38(10):1904-1907. |
| 作者姓名： | 张玉琦 徐文炜 袁国桢 姚建军 程灶火 刘朝军 刘庆海 王爱荣 史桂芝 王宝恒 张长松 成义仁 李克 |
| 作者单位： | 1. 南京医科大学附属无锡精神卫生中心,无锡,214151 2. 山东省安康院 3. 汕头大学医学院分子遗传学教研室 |
| 基金项目： | 江苏省无锡市社会发展科技指导性计划项目，广东省汕头市科技计划项目 |
| 摘 要： | 目的]探讨色氨酸羟化酶2(TPH2)基因rs7305115单核苷酸多态性与单相抑郁症及其症状表型的遗传关联性。方法]提取197例单相抑郁症患者和225名健康对照者基因组DNA,采用聚合酶链反应(polymerase chain reaction PCR)扩增包括TPH2基因rs7305115位点的312bp基因组DNA片段及PCR产物直接测序。采用汉密顿抑郁量表(HAMD)评定病例组症状表型。结果]在第7外显子周围未发现其他的单核苷酸多态性。单相抑郁患者和健康对照者TPH2rs7305115基因型和等位基因频率差异无统计学意义(P﹥0.05)。病例组中症状表型焦虑/躯体化、体重、日夜变化、迟缓、睡眠障碍在3种基因型间分布差异无统计学意义(P﹥0.05),而认知障碍和绝望感AA基因型与AG及GG基因型间差异均有统计学意义(P﹤0.01)。结论]TPH2基因rs7305115单核苷酸多态性与单相抑郁无明显关联,与认知障碍和绝望感可能相关。 |
| 关 键 词： | 单相抑郁症 TPH2基因 单核苷酸多态性 病例-对照研究 |
ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM OF A NOVEL TRYPTOPHAN HYDROXYLASE ISOFORM (TPH2) GENE RS7305115 AND UNIPOLAR DEPRESSION AND SYMPTOM PHENOTYPES |
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| ZHANG Yu-qi,XU Wen-wei,YUAN Guo-zheng,et al..ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISM OF A NOVEL TRYPTOPHAN HYDROXYLASE ISOFORM (TPH2) GENE RS7305115 AND UNIPOLAR DEPRESSION AND SYMPTOM PHENOTYPES[J].Modern Preventive Medicine,2011,38(10):1904-1907. | |
| Authors: | ZHANG Yu-qi XU Wen-wei YUAN Guo-zheng |
| Institution: | ZHANG Yu-qi,XU Wen-wei,YUAN Guo-zheng,et al.(Wuxi Mental Health Center,Nanjing Medical College,Wuxi 214151,China) |
| Abstract: | Objective]To explore the relation between single nucleotide polymorphism analysis of a novel tryptophan hydroxylase isoform(TPH2)gene rs7305115 and and symptom phenotypes in Han nationality of Chinese.Methods]Specimens of peripheral blood were collected from Chinese 197 depression and 225 controls.Polymerase chain reaction(PCR)of a novel tryptophan hydroxylase isoform(TPH2)gene rs7305115 in length 312bp was analyzed by direct sequencing,and the symptom phenotypes of cases was evaluated by the Hamilton Rat... |
| Keywords: | Depression TPH2gene Single nucleotide polymorphism Case-control studies |
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