不同时点分别结扎左、右颈总动脉建立的大鼠血管性痴呆模型血流变学及生化学研究

目的]建立不同时点分别结扎左、右颈总动脉建立的大鼠改良血管性痴呆模型,观察血流变学指标及生物化学指标的变化,以便更好的了解血管性痴呆的病理生理过程。方法]采取间隔3d分2次结扎双侧颈总动脉建立血管性痴呆模型,术后8周测定学习记忆能力后,取血检测血流变学指标及制备脑组织匀浆检测TNF-α、IL-1β、NO、NOS、SOD、MDA。结果]与假手术组比较,学流变学指标明显异常,TNF-α、IL-1β、NO、MDA含量明显升高,NOS活性显著增加,SOD活性明显降低。结论]不同时点分别结扎左、右颈总动脉建造大鼠血管性痴呆模型的血流变学异常,多种生化指标改变,符合血管性痴呆病理生理过程是一种较为理想方法。

STUDY ON THE IMPROVEMENT OF VASCULAR DEMENTIA MODEL IN RATS

Objective] To establish a better permanent bilateral common carotid artery occlusion method to establish the vascular dementia model,and observe the effect of hemorrheology and biochemistry indexes,so as to better understand of Pathophysiology process of vascular dementia.Methods] The bilateral common carotid arteries were occluded in two times operation at 3 days interval to establish the vascular dementia model,and we tested the learning and memory after operation for 8 weeks,and we tested the hemorrheo...