幽门螺杆菌感染与缺血性脑卒中发病风险相关性的Meta分析

目的 系统评价幽门螺杆菌（Hp）感染与缺血性脑卒中（IS）发病风险的相关性。方法 计算机检索PubMed、EMBASE、The Cochrane Library、CBM、CNKI、WanFang、VIP等数据库。搜集Hp感染与IS发病风险相关性的观察性研究，检索时限从建库至2020年12月。由2名研究者独立筛选文献、提取信息并评价纳入研究的质量及偏倚风险，采用Stata软件进行meta分析。结果 共纳入26项比较，发表在24篇文献中，涉及111 059例患者，包括19项病例对照研究，7项队列研究。文献质量均评价为中高水平。meta分析结果显示:Hp感染可增加IS的发病风险 OR（95%CI） = 1.52（1.31～1.77），P＜0.01]。以研究类型病例对照研究（OR = 1.69）]、Hp感染检测指标Hp - IgG（OR = 1.42）、CagA - IgG（OR = 2.09）、C - 14（OR = 3.30）]、卒中病因分型大动脉粥样硬化型（OR = 2.69）]为分类依据进行亚组分析，发现Hp感染可以增加IS的发病风险。结论 Hp感染与IS发病风险具有一定的相关性，但该结论尚需更多高质量病因学研究进一步证实。

Helicobacter pylori infection and the risk of ischemic stroke: a meta-analysis

Objective To systematically evaluate the association between Helicobacter pylori(Hp) infection and ischemic stroke (IS). Methods The Cochrane library, CBM, CNKI, Wanfang and VIP databases were searched for observational studies on the relationship between Hp infection and the risk of IS from the establishment of the database to December 2020. Two researchers independently screened the literature, extracted information, and evaluated the quality and risk of bias of the included studies. Meta-analysis was performed with the use of Stata software. Results A total of 26 comparisons involving 111 059 patients were included in 24 articles, including 19 case-control studies and seven cohort studies. The literature was of middle or high level. Results of this meta-analysis showed that Hp infection significantly increased the risk of IS OR (95%CI) =1.52 (1.31-1.77), P＜0.01]. Subgroup analyses showed that Hp infection was significantly related to IS case-control study (OR=1.69)], detection of infection HP-IgG (OR=1.42), CagA-IgG (OR=2.09), C-14 (OR=3.30)], and the etiological classification of strokelarge artery atherosclerotic(OR=2.69)]. Conclusion There is a significant correlation between Hp infection and IS, but this conclusion needs further confirmation by more high-quality etiological studies.