IL - 22与糖尿病关系的研究进展

目的 本文总结了近年来白细胞介素22 (interleukin 22, IL - 22)与糖尿病(diabetes mellitus，DM)发病关系的研究，希望能为DM的防治及病情评估提供较为可行的策略靶点。方法 本文资料来源于中国知网、PubMed等数据库，以IL - 22、糖尿病、胰岛素、糖异生等关键词进行检索得到。结果 IL - 22可增加胰岛素分泌、促进胰岛素信号转导及维持葡萄糖稳态，参与DM发生、发展及病情演变。结论 IL - 22可通过多个环节参与DM的发病及病情演变，以IL - 22为靶点对于防治DM具有重要参考价值。

Research progress on the relationship of IL-22 and diabetes mellitus

Objective To summarize the relationship between Interleukin-22(IL-22) and the onset of diabetes mellitus, to provide a feasible target for the prevention and treatment of DM and disease assessment. Methods The data were collected from CNKI, PubMed and other databases with “IL-22”, “diabetes”, “insulin” and “gluconeogenesis” as keywords. Results IL-22 can increase insulin secretion, promote insulin signaling and maintain glucose homeostasis, and participate in DM onset, development and disease evolution. Conclusion IL-22 is involved in the pathogenesis and evolution of DM through several links, and using IL-22 as a target has important reference value for the prevention and treatment of DM.