2009-2013年某医院鲍氏不动杆菌的 分布及耐药性变迁

摘要:目的　研究2009-2013年某医院临床分离鲍氏不动杆菌的分布及耐药性的变迁。方法　回顾分析2009-2013年我院住院患者标本中分离的鲍氏不动杆菌的分布情况及其药敏试验结果，采用仪器法和纸片扩散法检测鲍氏不动杆菌对常用10种抗菌药物的耐药性，分析5年来鲍氏不动杆菌的分布特点及耐药性变迁。结果　5年间共分离到鲍氏不动杆菌1200株，2009-2011年其数量和所占总分离菌株的构成比呈逐年递增。标本类型中痰、分泌物和血占分离标本的前3位，痰标本最常见，占82.83%。鲍氏不动杆菌对亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦的耐药率呈逐年上升趋势。对环丙沙星耐药率最高，平均达77.27%。结论　5年来鲍氏不动杆菌对部分抗菌药物的耐药性呈升高趋势，应加强鲍氏不动杆菌的耐药性监测，依据体外药敏结果合理使用抗菌药物。

Distribution and antibiotic resistance of acinetobacter baumannii, 2009-2013

Abstract: Objective To investigate the distribution and antibiotic resistance of Acinetobacter baumannii isolated from inpatients from 2009 to 2013. Methods We analyzed retrospectively the distribution and the antimicrobial resistance of Acinetobacter baumanni isolated from inpatients during 2009 to 2013. The drug resistance to 10 kinds of common antibiotics of Acinetobacter baumannii was tested by methods the minimum inhibitory concentration (MIC), and some antimicrobial susceptibility test used K-B. Results A total of 1200 strains of Acinetobacter baumannii were separated and the number and proportion were showed an increasing trend from 2009 to 2011. The top three types of specimens were sputum (82.83%), excreta and blood. Acinetobacter baumannii was highly resistant to most of clinical antibiotics and some of antibiotics showed a gradually increasing trend. Its resistance to imipenem, cefoperazone/shubatan, piperacillin/shubatan showed rising trends year by year. Its resistance to ciprofloxacin was the highest, up to 77.27%. Conclusion The antibiotic drug resistance of Acinetobacter baumanni showed an increasing trend. The monitoring of Acinetobacter baumannii resistance to drugs should be strengthened. Clinical doctors should emphasize microbioiogical culture and drugs using should be based on antimicrobial susceptibility results.