乙肝疫苗接种无弱应答与遗传因素关系的研究

为了研究乙肝疫苗接种无弱应答的发生机制，本次研究首先对经过严格筛选的无弱应答和强应答（对照）者一级亲属（分别有８０和７９人）自然状况下的ＨＢＶ感染率进行比较。结果显示，无弱应答组ＨＢＶ的感染率为３３．８％，明显高于强应答组的１５．２％（Ｐ＝０．０１１）。在此基础上，进一步观察了无弱应答和强应答组一组亲属中乙肝三项指标全阴性和单项抗－ＨＢｓ低水平者５６人（分别为２７和２９人）接种乙肝疫苗后Ｔ７时抗－ＨＢｓ的分布情况，两组分别随访到２４人和２８人，结果无弱应答组的ＧＭＴ显著低于强应答组的ＧＭＴ。表明无弱应答具有一定的遗传易患性。

THE STUDY ON RELATIONSHIP BETWEEN NON-AND-HYPORESPONSES TO HEPATITIS B VACCINE AND GENETIC FACTOR

This study,first relatives of non-and-hyporesponders and hyperresponders(80 and 79 respectively) were recruited as the study objects.With the factors which may influenced the HBV infection identical in the groups of first relatives,we investigated the HBV infection rate and levels of anti-HBs of the main relatives under natural state,the results showed that HBV rate of non-and-hyporesponders(33 8%) was higher than that of hyperresponders(15 2%, P =0 011);56 first relatives with negative HBsAg and anti-HBc,and low level of anti-HBs were inoculated at 0,1 and 6 month,blood samples were collected at 7th month with the factors which influenced anti-HBs response identical between the groups.After the vaccination,the overall anti-HBs GMT of non-and-hyporesponder group were remarkably lower than that of hyperresponder;These indicated that genetics played a role in the liablity to HBV infection in non-and-hyporesponders.