| 大鼠开胸停跳体外循环模型的建立 |
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| 引用本文： | 高光洁,宋丹丹,张铁铮.大鼠开胸停跳体外循环模型的建立[J].现代预防医学,2011,38(11):2117-2119. |
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| 作者姓名： | 高光洁 宋丹丹 张铁铮 |
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| 作者单位： | 1. 中国人民解放军第四六三医院麻醉科,沈阳,110042
2. 中国人民解放军沈阳军区总医院麻醉科 |
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| 摘 要： | 目的]建立适合研究体外循环期间脏器损伤、全身炎症反应机制及评估相关保护措施的模型。方法]Wistar大鼠10只进行麻醉建立体外循环心脏停跳复跳监测各时相MAP、HR、直肠温及血气分析。结果]MAP、HR、直肠温及血气分析这些变化过程与临床实践基本相符。结论]大鼠心脏停跳、复跳模型完全贴近临床,是研究体外循环心肺损伤机制及评价各种心肺保护措施的良好实验工具。
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| 关 键 词： | 体外循环 心肺损伤 实验工具 |
THE ESTABLISHMENT OF THE RAT MODEL OF CPB AFTER THORACOTOMY AND CARDIAC ARREST |
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| GAO Guang-jie,SONG Dan-dan,ZHANG Tie-zheng.THE ESTABLISHMENT OF THE RAT MODEL OF CPB AFTER THORACOTOMY AND CARDIAC ARREST[J].Modern Preventive Medicine,2011,38(11):2117-2119. |
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| Authors: | GAO Guang-jie SONG Dan-dan ZHANG Tie-zheng |
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| Institution: | GAO Guang-jie,SONG Dan-dan,ZHANG Tie-zheng.(Department of Anesthesiology of 463 Hospital of Chinese PLA,Shenyang 110042,China) |
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| Abstract: | Objective] In order to construct a model which could be used for researching the organ damage,systemic inflammatory reaction mechanism,evaluating the protection measures.Methods]Ten mice were anesthetized and constructed cardiopulmonary bypass,cardiac arrest and resuscitation,monitored MAP,HR,temperature of rectum and blood gas analysis.Results]All the indicators were consistent with the clinical practice.Conclusion]The model of mouse cardiac arrest and resuscitation are consistent with the clinical pra... |
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| Keywords: | Cardiopulmonary bypass Damage of heart and lung Experimental tool |
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