| 阿尔茨海默病患者血液中神经递质含量与分布特点探讨 |
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| 引用本文： | 万爱兰,袁也丰,郭明,黄河浪,叶冬青,吴磊.阿尔茨海默病患者血液中神经递质含量与分布特点探讨[J].现代预防医学,2011,38(12):2314-2316. |
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| 作者姓名： | 万爱兰 袁也丰 郭明 黄河浪 叶冬青 吴磊 |
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| 作者单位： | 1. 南昌大学一附院心身医学科,南昌,330006
2. 南昌大学公共卫生学院 |
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| 基金项目： | 江西省教育厅2008年度科技计划项目(GJJ08079) |
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| 摘 要： | 目的]探究南昌部分社区养老机构及医院阿尔茨海默病(AD)的患病现状和影响因素,为AD的预防和控制提供参考。方法]对南昌部分社区养老机构及医院≥60岁的AD患者(52例)和对照(57例)实施问卷调查,采用放射免疫分析法对五羟色胺(5-HT)、多巴胺(DA)进行检测分析。结果](1)AD患者中男性占29.8%,女性为70.2%,对所有的AD患者按轻、中、重分型,依次为中度(63.8%),重度(25.5%),轻度(10.6%)。(2)5-HT与DA的含量在3个不同年龄段的两组人群中表现出统计学差异,即非AD人群5-HT与DA的含量明显高于AD者。(3)多因素Logistic回归分析提示,文化程度高对AD的发生具有保护性效应(OR=0.252,P=0.050);危险性因素:5-HT含量低最为明显(OR=12.588,P=0.001);DA含量低也表现出较大危险(OR=6.634,P=0.002)。结论]南昌部分社区养老机构及医院的AD患者以女性多见;分型以中度型为主;5-HT含量低和DA含量低为AD的危险因素,文化程度高为AD的保护因素。
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| 关 键 词： | 阿尔茨海默病(AD) 神经递质 多巴胺(DA) 五羟色胺(5-HT) |
STUDY ON THE CONTENT AND DISTRIBUTION CHARACTERISTICS OF NEUROTRANSMITTER IN THE BLOOD OF ALZHEIMER DISEASES PATIENTS |
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| WAN Ai-lan,YUAN Ye-feng,GUO Ming,et al..STUDY ON THE CONTENT AND DISTRIBUTION CHARACTERISTICS OF NEUROTRANSMITTER IN THE BLOOD OF ALZHEIMER DISEASES PATIENTS[J].Modern Preventive Medicine,2011,38(12):2314-2316. |
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| Authors: | WAN Ai-lan YUAN Ye-feng GUO Ming |
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| Institution: | WAN Ai-lan,YUAN Ye-feng,GUO Ming,et al.(The First Affiliated Hospital of Nanchang University,Nanchang 330006,China) |
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| Abstract: | Objective]To explore the current situation and the influential factors about the Alzheimer Disease in some of pension institutions and hospitals of Nanchang,and find out some evidences for more intervention and control.Methods]52 patient cases and 57 control cases,who were older than 60 years,were tested by questionnaire and serotonin(5-HT),dopamine(DA)examined by radioimmunoassay.Results]In the Alzheimer Disease patients,male was accounted for 29.8%,female was accounted for 70.2%.For patients number of ... |
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| Keywords: | Alzheimer Disease Neurotransmitter Dopamine(DA) Serotonin(5-HT) |
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