| 吸烟与肝癌关系的Meta分析 |
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| 引用本文： | 刘银梅,沈月平,刘娜,胡文斌,刘雯.吸烟与肝癌关系的Meta分析[J].现代预防医学,2010,37(20). |
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| 作者姓名： | 刘银梅 沈月平 刘娜 胡文斌 刘雯 |
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| 作者单位： | 江苏苏州大学医学部放射医学与公共卫生学院流行病与卫生统计教研室; |
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| 基金项目： | 国家自然科学基金，苏州大学医学发展基金重点项目 |
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| 摘 要： | 目的]采用Meta分析法探讨吸烟与肝癌发病的相关性,为进行人群健康教育和预防决策提供依据。方法]以肝癌组与对照组人群是否吸烟的OR值为效应指标,根据一致性检验的结果,选择随机效应模型对OR值进行合并并进行偏倚评估。采用GLS法检验吸烟量与OR值的剂量反应关系。结果]共查到符合要求的国内外文献50篇,病例和对照数分别为10228、22312例。经异质性检验,50项研究结果存在异质性(q=267.75,P﹤0.0001),经过随机效应模型估计,以不吸烟人群为参比组,吸烟人群患肝癌的合并OR值为1.43(95%CI1.25～1.63)。按地域(亚洲、中北美洲、欧洲)合并OR值(95%CI)分别为1.46(1.24～1.72)、1.65(1.29～2.10)和1.14(0.83～1.57),按国别(国内、国外)合并OR值(95%CI)为1.32(1.07～1.63)和1.51(1.28～1.78),按对照选取的人群(正常人、非肝癌病人)合并OR值(95%CI)为1.41(1.21～1.64)和1.44(1.18～1.75),按研究设计的类型(病例对照、巢式病例对照)合并OR值(95%CI)为1.47(1.29～1.68)和1.00(0.54～1.82),OR值较一致。随吸烟量增加,肝癌发生风险在增加,呈现显著剂量反应关系(Z=4.76,P﹤0.0001)。结论]吸烟是肝癌发病的危险因素。
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| 关 键 词： | 肝癌 吸烟 Meta分析 |
META-ANALYSIS OF THE ASSOCIATION BETWEEN SMOKING AND LIVER CANCER |
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| LIU Yin-mei,SHEN Yue-ping,LIU Na,et al..META-ANALYSIS OF THE ASSOCIATION BETWEEN SMOKING AND LIVER CANCER[J].Modern Preventive Medicine,2010,37(20). |
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| Authors: | LIU Yin-mei SHEN Yue-ping LIU Na |
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| Institution: | LIU Yin-mei,SHEN Yue-ping,LIU Na,et al.(Department of Epidemiology and Biostatistics,School of Ra-diation & Public Heath,Soochow University,Suzhou 215123,China) |
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| Abstract: | Objective] To offer scientific basis for health education and decision of prevention,by exploring smoking associated with liver cancer risk through meta-analysis.Methods] Taking into account the possibility of heterogeneity test,random effect Meta-analysis model was used to calculate the combined odds Ratio(OR) of association strength between smoking and liver cancer,meanwhile publication bias was also evaluated.Generalized least squares(GLS) for trend estimation of summarized dose-response relationship b... |
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| Keywords: | Liver cancer Smoking Meta-analysis |
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