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乙肝免疫球蛋白阻断HBV父婴、母婴传播的观察
引用本文:杨静,邵兴兰,尤世刚.乙肝免疫球蛋白阻断HBV父婴、母婴传播的观察[J].现代预防医学,2006,33(5):806-806,813.
作者姓名:杨静  邵兴兰  尤世刚
作者单位:湖北省郧阳医学院附属人民医院,十堰,442000
摘    要:目的:用乙肝免疫球蛋白(HBIG)阻断乙肝病毒携带者孕妇宫内感染(父婴、母婴垂直传播)。方法:对乙肝病毒携带者的孕妇自28周起每月肌注200IU的HBIG1剂(28W、32W、36W),产前共注射3剂。分娩时新生儿抽脐静脉血查乙肝病毒血清标志物(HBVM)。结果:83例乙肝病毒携带者所生的新生儿3例感染HBV,HBV宫内感染率为3.62%。母婴传播阻断率95.95%(71/74);父婴传播阻断率100.00(9/9)。结论:乙肝病毒携带者的孕妇在孕28W、32W、36W分别注射HBIG200IU3剂。可有效预防胎儿HBV宫内感染。

关 键 词:乙肝免疫球蛋白  阻断  乙肝病毒  父婴传播  母婴传播
文章编号:1003-8507(2006)05-0806-02
收稿时间:2005-08-01
修稿时间:2005-08-01

THE OBSERVATION OF USING HBIG TO DETER THE HBV DISSEMINATION FORM PARENTS TO BABIES
YANG Jing,SHAO Xing-lan,YOU Shi-gang.THE OBSERVATION OF USING HBIG TO DETER THE HBV DISSEMINATION FORM PARENTS TO BABIES[J].Modern Preventive Medicine,2006,33(5):806-806,813.
Authors:YANG Jing  SHAO Xing-lan  YOU Shi-gang
Abstract:Objective:Using HBIG to abscond the HBV intrauterine infection from the carrier-HBV pregnant women to their babies(Dissemination from father to bady.Dissemination from mother to bady).Methods:The carrier-HBV pregnant women were injected with HBIG 200 IU monthly form the 28 th week during pregnancy.The injection were 3 times totally(28 w,32 w,36 w).The navel vein bloods of infants were tested for HBVM when it was born.Results:Among the 83 babies whom born from the peoples HBV mothers,3 were infected by HBV.The infection rate was 3.62%.The absconding rate of infection from mother to baby was 95.95%(71/74),and which from father to baby was 100%(9/9).Conclusion:By injection to the carrier-HBV pregnant women with HBIG 200 IU monthly(28 w,32 w,36 w)may prevent HBV intrauterine infection effectively.
Keywords:HBIG  Abscond  HBV  Dissemination Father-Bady  Dissemination mother-Bady
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