| 核酸对小鼠S-180肿瘤生长的抑制作用及其机制研究 |
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| 引用本文： | 潘洪志,陈文华,李蓉,欧阳吉芳,李恕.核酸对小鼠S-180肿瘤生长的抑制作用及其机制研究[J].现代预防医学,2006,33(3):391-392. |
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| 作者姓名： | 潘洪志 陈文华 李蓉 欧阳吉芳 李恕 |
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| 作者单位： | 1. 哈尔滨医科大学公共卫生学院,哈尔滨,150001
2. 珍奥集团股份有限公司 |
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| 摘 要： | 目的：观察核酸的体内抗肿瘤作用.方法：小鼠给予饮食核酸15 d后,腋下注射S-180肉瘤瘤株,建立荷瘤小鼠模型,观察荷瘤小鼠肿瘤生长情况及对小鼠免疫系统的影响.结果：核酸具有明显的抗肿瘤作用,能够抑制肿瘤细胞的生长,且能延长荷瘤小鼠生存天数;能够增强小鼠脾脏T淋巴细胞增殖能力,提高自然杀伤细胞（NK）活性.结论：饮食核酸可能具有一定的抗肿瘤作用,其作用可能是通过增强免疫系统功能来实现的.
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| 关 键 词： | 核酸 肿瘤 小鼠 |
| 文章编号： | 1003-8507（2006）03-0391-02 |
| 收稿时间： | 2005-04-30 |
| 修稿时间： | 2005年4月30日 |
MECHANISM AND INHIBITION EFFECT OF NUCLEIC ACID ON TUMOR GROWTH IN S180-BEARING MICE |
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| PAN Hong-zhi, CHEN Wen-hua, LI Rong,et al..MECHANISM AND INHIBITION EFFECT OF NUCLEIC ACID ON TUMOR GROWTH IN S180-BEARING MICE[J].Modern Preventive Medicine,2006,33(3):391-392. |
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| Authors: | PAN Hong-zhi CHEN Wen-hua LI Rong |
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| Institution: | Public Health School of Harbin Medical University, Harbin, 150001. |
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| Abstract: | Objective:To observe the effect of Nucleic Acid on tumor in mice.Methods:The mice were given nucleic acid by oral. S180-bearing mice were used as animal model.The effects of nucleic acid on tumor weight,spleen lymphocyte proliferation and NK activity were examined.Results:Nucleic acid could markedly decrease tumor weight,inhibit the growth of cancer cell,prolong the survival days.Nucleic acid could promote spleen lymphocyte proliferation,NK activity significantly(P<0.05).Conclusion:Nucleic acid could inhibit the growth of S180 tumor.The antitumor effect may be related to its immune function. |
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| Keywords: | S-180 |
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