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A randomized,double-blind study of two combined oral contraceptives containing the same progestogen,but different estrogens
Authors:Suporn Koetsawang  AV Mandlekar  Usha R Krishna  VN Purandare  CK Deshpande  SC Chew  Rosilind Fong  SS Ratnam  L Kovacs  S Zalanyi  A Tekulics  M Briggs  MA Belsey  PE Hall  RA Parker
Institution:Special Programme of Research, Development and Research Training in Human Reproduction World Health Organization Geneva, Switzerland;Siriraj Hospital, Mahidol University, Bangkok, Thailand;KEM Hospital and Seth G. S. Medical College, Bombay, India;Kandang Kerbau Hospital University of Singapore, Singapore, Republic of Singapore;University Medical School, Szeged, Hungary;Deakin University, New South Wales, Australia;World Health Organization, Geneva, Switzerland
Abstract:An investigation correlating scanning electron microscopic observations with sperm penetration tests carried out on cervical mucus under the influence of low-dose continuous progestogen (Norgestrienone) is presented. The results demonstrate that such type of contraceptive is involved in drastic alterations of mid-cycle cervical mucus at the macromolecular level. The meshwork which constitutes the infrastructure of the cervical secretion appears to be greatly tightened as a result of the treatment, thus giving the woof a general appearance typical of cervical mucus in the late luteal phase. The immobilizing effect of such modified mucus on spermatozoa is demonstrated and the duration of effectiveness after the administration of a last pill on the morning of day 13 is determined.
Keywords:Requests for reprints: Dr  M  A  Belsey  Medical Officer Special Programme of Research  Development and Research Training in Human Reproduction World Health Organization 1211 Geneva 27  Switzerland  
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