| CYP1A1基因多态性与女性子宫内膜癌易感性关系的Meta分析 |
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| 引用本文： | 张小围,刘贵鹏.CYP1A1基因多态性与女性子宫内膜癌易感性关系的Meta分析[J].中国生育健康杂志,2010,21(3):134-137. |
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| 作者姓名： | 张小围 刘贵鹏 |
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| 作者单位： | 中国医科大学附属盛京医第一微创妇科,沈阳,110162 |
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| 摘 要： | 目的综合评价CYP1A1基因多态性与女性子宫内膜癌遗传易感性的关联度。方法通过检索万方、CNKI、维普和PUBMED数据库，获取CYP1A1基因多态性与女性子宫内膜癌易感性关系的病例-对照研究。以子宫内膜癌组与对照组人群基因型分布的OR值为效应指标，采用REVMAN4．2软件进行Meta分析，并根据一致性检验的结果选用合适的模型进行数据的合并。结果入选文献共4篇，其中英文文献1篇，中文文献3篇，累计病例数和对照数分别为908和1585例。CYP1A1CC（纯合子模型）合并后OR值为1．19（95％CI：0．81～1．74）。CYP1A1（杂合子模型）合并后OR值为1．37（95％CI：1．12—1．67），CYP1A1等位基因C合并后OR值为1．19（95％CI：1．03—1．39）。结论CYP1A1的基因多态性与子宫内膜癌的易感性有关。
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| 关 键 词： | CYP1A1 基因多态性 子宫内膜癌 Meta分析 |
Relationship between polymorphism of CYP1A1 gene and endometrial cancer among females: a Meta-analysis |
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| ZHANG Xiaowei,LIU Guipeng.Relationship between polymorphism of CYP1A1 gene and endometrial cancer among females: a Meta-analysis[J].Chinese JOurnal of Reproductive Health,2010,21(3):134-137. |
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| Authors: | ZHANG Xiaowei LIU Guipeng |
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| Institution: | ZHANG Xiaowei,LIU Guipeng.Department of Minimally Invasive Gynecology,Shengjing Hospital,China Medical University,Shenyang 110003,China |
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| Abstract: | Objective To evaluate the relationship between CYP1A1 gene polymorphism and the risk of endometrial cancer among females.Methods A Meta-analysis was performed using published reports with a case-control design.Results Four case-control studies consisting of 908 endometrial cancer cases and 1 585 controls were included.Pooled odds ratio(OR) of CYP1A1 CC and CYP1A1 CT was computed with CYP1A1 TT as the reference group.Women carrying a CC genotype had an OR of 1.19(95% CI:0.81-1.74),and women carrying a CT gen... |
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| Keywords: | CYP1A1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
