山东某省级医院174例急性百草枯中毒患者特征分析

目的]了解急性百草枯中毒发生的特征和预后影响因素，为防治百草枯中毒提供针对性的科学依据。方法]收集山东某省级医院2003--2009年收治的急性百草枯中毒病例，根据住院患者病历中的关键字段内容建立数据库，摘录患者基本特征、治疗方式、治疗结局等有关内容进行分析。结果]该医院7年间共收治确诊急性口服百草枯中毒住院患者174例，其中死亡54例，病死率为31．0％，中毒人数有逐年增多的趋势。中毒者有明显的性别和职业差异（P〈0．05），中毒人群中农民占75．9％，且中毒具有一定的季节性，以夏季为主。百草枯的口服量影响治疗结局（P〈0．05）。吸附剂、血液净化治疗在改善患者治疗结局方面的差异无统计学意义。结论]百草枯中毒尚无肯定的特别有效的治疗手段。需加强百草枯的管理，采取综合措施以减少百草枯急性中毒的发生。

Charaeteritics of 174 Acute Paraquat Poisoning Cases in A Provincial Hospital of Shandong

To study the characteristics of acute paraquat poisoning and provide scientific bases for strategies to perform further prevention and therapy. Methods ] Medical history records of acute paraquat poisoning cases in a province-level hospital from 2003 to 2009 were collected in Shandong Province. Key information such as demographic information, therapeutics and outcome was extracted and put into computerized data base as well as deeply dug with statistical analyses. Results ] There were 174 hospitalized cases of acute paraquat poisoning due to oral swallow paraquat in this seven years. The fatality rate was 31.0%. There were gender （P 〈 0.05） and occupation （P 〈 0.05） differences among these patients, 75.9% patients were peasants. Most poisoning cases occurred in summer. Final outcomes were affected by the paraquat amount intaken. The statistics showed that the treatment with absorbants and blood purification had no contribution to paraquat poisoning cure. Conclusion ] There is no particularly effective means in treatment of paraquat poisoning. More stringent regulation should be emphasized to reduce the occurrence of acute paraquat poisoning and comprehensive therapeutic measures should be taken in the clinic.