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中国婴幼儿轮状病毒腹泻的流行病学和疾病负担研究进展
引用本文:张丽杰,方安.中国婴幼儿轮状病毒腹泻的流行病学和疾病负担研究进展[J].中国计划免疫,2007,13(2):186-191.
作者姓名:张丽杰  方安
作者单位:中国疾病预防控制中心病毒病预防控制所 北京100052(张丽杰),中国医学科学院图书馆 北京100005(方安)
摘    要:目的为全面了解中国轮状病毒(Rotavirus,RV)腹泻的流行情况、疾病负担以及流行毒株特征,促进RV疫苗的开发和应用,对1979~2005年公开发表的关于RV研究的文献进行检索和综述。结果显示,在全年开展RV腹泻监测的医院中,住院腹泻患儿RV检出率中位数是46%,门诊腹泻患儿RV检出率中位数是29%,而社区腹泻患儿RV检出率只占10%。中国RV腹泻以秋冬季为流行高峰,主要流行时间从10月~次年2月。总体上流行株以G1血清型为主,2001年以后则以G3型为主。P基因型则是以P8]型为优势株。中国RV毒株G-P组合型呈现出多样性的特征,提示了长期开展RV监测的必要性。

关 键 词:轮状病毒  流行病学  疾病负担
文章编号:1006-916X(2007)02-0186-06
修稿时间:2006年11月30

Development on the Epidemiology and Disease Burden of Rotavirus in China
ZHANG Li-jie,FANG An.Development on the Epidemiology and Disease Burden of Rotavirus in China[J].Chinese Journal of Vaccines and Immunization,2007,13(2):186-191.
Authors:ZHANG Li-jie  FANG An
Abstract:We reviewed the studies on rotavirus(RV)published during 1979 to 2005 in China to understand the epidemiology of RV diarrhea,estimate the disease burden,and to enhance the development and implementation of RV vaccine.The results showed that the median detection rate of RV in children with diarrhea among inpatient and outpatient were 46% and 29% respectively.RV was less detected in children with diarrhea in communities (10%).A peak season of rotavirus infection was observed from October through next February.G1 serotype was the predominant strain in China overall,but G3 had been the most common type since 2001.P was the main genotype.The diversity of G-P combination indicated that it is necessary to conduct long-term rotavirus strain surveillance in China.
Keywords:Rotavirus  Epidemiology  Disease burden
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