| N—乙酰半胱氨酸对二甲基甲酰胺所致急性肝损伤的保护作用 |
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| 引用本文： | 郭凤华,杨文福,穆进军,姚汝琳,李美丽.N—乙酰半胱氨酸对二甲基甲酰胺所致急性肝损伤的保护作用[J].职业与健康,2002,18(8):8-10. |
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| 作者姓名： | 郭凤华 杨文福 穆进军 姚汝琳 李美丽 |
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| 作者单位： | 1. 山西医科大学公共卫生学院,030001
2. 山西省忻州云河医院 |
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| 摘 要： | 目的 探讨N-乙酰半胱氨酸(NAC)对二甲基甲酰胺(DMF)所致急性肝损害的保护作用。方法 给小鼠腹腔注射一次1800mg/kg DMF后用NAC灌胃。测定血清山梨醇脱氢酶(SDH)、丙氨酰氨基转移酶(ALT)、甘胆酸(CG)、肝脏谷胱甘肽(GSH)、Na~ K~ -ATP酶、Ca~(2 )-ATP酶,观察肝脏病理改变。结果 与单纯染毒组比较,染毒后连续口服NAC组血清SDH、ALT、CG明显降低(P<0.05),肝脏GSH含量升高,Na~ K~ -ATP酶、Ca~(2 )-ATP酶活性增高(P<0.05),肝脏病理改变减轻。结论 NAC对DMF所致急性肝损伤有一定保护作用。
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| 关 键 词： | N-乙酰半脱氨酸 二甲基甲酰胺 肝损伤 |
| 文章编号： | 1004-1257(2002)08-0008-03 |
Protective function of N - acetylcysteine on acute liver injuries induced by dimethyl formamide |
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| GUO Fenghua YANG Wenfu,etc..Protective function of N - acetylcysteine on acute liver injuries induced by dimethyl formamide[J].Occupation and Health,2002,18(8):8-10. |
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| Authors: | GUO Fenghua YANG Wenfu etc |
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| Abstract: | Objective ] To study the protective function of N - acetylcysteine on acute liver injuries induced by dimethyl formamide. Methods] Mice injected with DMF of 1 800 mg/kg were given NAC. The levels of sorbitol dehydrogenase (SDH), alanine transaminase (ALT) , glycocholicacid (CG) , liver glutathione (GSH) , Na - ATPase and Ca2 - ATPase in liver were detected. Pathological changes in liver were examined. Results] Compared with DMF-treated mice, SDH, ALT and CG in the NAC group significantly decreased, GSH content increased, the activity of Na - ATPase and Ca - ATPase increased ( P < 0.05) , and pathological changes in liver decreased. Conclusion] NAC and CMF have a protective function on acute liver injuries. |
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| Keywords: | N - acetylcysteine Dimethyl formamide Liver injury |
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