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Structural basis for oseltamivir resistance of influenza viruses
Authors:PJ Collins  LF Haire  YP Lin  J Liu  RJ Russell  PA Walker  SR Martin  RS Daniels  V Gregory  JJ Skehel  SJ Gamblin  AJ Hay
Institution:1. MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK;2. Interdisciplinary Centre for Human and Avian Influenza Research, School of Biology, University of St Andrews, Fife KY16 9ST, UK
Abstract:Oseltamivir, one of the two anti-neuraminidase drugs, is currently the most widely used drug against influenza. Resistance to the drug has occurred infrequently among different viruses in response to drug treatment, including A H5N1 viruses, but most notably has emerged among recently circulating A H1N1 viruses and has spread throughout the population in the absence of drug use. Crystal structures of enzyme–drug complexes, together with enzymatic properties, of mutants of H5N1 neuraminidase have provided explanations for high level oseltamivir resistance due to the common H275Y mutation, with retention of zanamivir susceptibility, and intermediate level resistance due to the N295S mutation. Complementation of enhanced NA activity due to a D344N mutation by the H275Y mutation suggests an explanation for the recent emergence and predominance of oseltamivir-resistant influenza A H1N1 viruses.
Keywords:Influenza H5N1  Oseltamivir resistance  H275Y mutation
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