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Association between reactogenicity and SARS-CoV-2 antibodies after the second dose of the BNT162b2 COVID-19 vaccine
Institution:1. Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan;2. Department of Laboratory Testing, Center Hospital of the National Center for the Global Health and Medicine, Tokyo, Japan;3. Department of Academic-Industrial Partnerships Promotion, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan;4. Department of Refractory Viral Infection, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;5. Division of Core Diagnostics, Abbott Japan LLC, Tokyo, Japan;6. Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;7. Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan
Abstract:High vaccine reactogenicities may reflect stronger immune responses, but the epidemiological evidence for coronavirus disease 2019 (COVID-19) vaccines is sparse and inconsistent. We observed that a fever of ≥38℃ after two doses of the BNT162b2 vaccine was associated with higher severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike IgG titers.
Keywords:Reactogenicity  Spike IgG titer  SARS-CoV-2  Fever  BNT162b2 vaccine
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