Efficacy of clade 2.3.2 H5 commercial vaccines in protecting chickens from clade 2.3.4.4 H5N8 highly pathogenic avian influenza infection |
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| Institution: | 1. Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea;2. Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea;1. Southeast Poultry Research Laboratory, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, United States;2. Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Padua, Italy;3. Avian Diseases Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea;1. State Key Laboratory of Emerging Infectious Diseases and Center of Influenza Research, The University of Hong Kong, Hong Kong Special Administrative Region, China;2. International Institution of Infection and Immunity, Shantou University Medical College, Shantou, China;3. Duke-NUS Graduate Medical School, 8 College Road, 169857, Singapore;4. Duke Global Health Institute, Duke University, Box 90519, Durham, NC 27708, United States;1. USDA SEPRL, Athens, GA, USA;2. Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road N.E., Atlanta, GA, USA;3. Medigen, Inc., 8420 Gas House Pike, Suite S, Frederick, MD, USA;1. Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom;2. Animal and Plant Quarantine Agency (QIA), 175 Anyangro, Anyangsi, Gyeonggido 430-757, Republic of Korea;3. Department of Virology, Animal and Plant Health Agency (APHA), Weybridge KT15 3NB, United Kingdom;4. Biological Control and Spatial Ecology, Université Libre de Bruxelles, B-1050 Brussels, Belgium;5. Fonds National de la Recherche Scientifique, 1080 Molenbeek-Saint-Jean, Belgium |
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| Abstract: | Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed. |
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| Keywords: | Highly pathogenic avian influenza H5N8 Vaccine Chicken |
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