New 1-indanone thiosemicarbazone derivatives active against BVDV |
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Authors: | Finkielsztein Liliana M Castro Eliana F Fabián Lucas E Moltrasio Graciela Y Campos Rodolfo H Cavallaro Lucía V Moglioni Albertina G |
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Institution: | Cátedra de Química Orgánica III, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina. |
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Abstract: | Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI=80.29) than that of ribavirin (SI=11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus. |
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