婴幼儿哮喘与支气管哮喘的遗传相关性研究

目的 探讨婴幼儿哮喘及支气管哮喘的遗传方式, 观察两者的遗传相关性, 为哮喘的三级预防提供理论依据。方法 通过Falconer回归法估计婴幼儿哮喘与支气管哮喘的遗传度, Logistic回归分析总结两者的主要危险因素, S-N-K法方差分析进行比较。结果 婴幼儿哮喘的遗传度为(80.53±7.85)%, 支气管哮喘的遗传度为(78.87±6.99)%, 两者危险因素比较无统计学意义(P>0.05)。结论 遗传因素在哮喘的发生、发展中起主要作用, 其他危险因素起协同作用, 两者具有密切相关性。因此预防婴幼儿哮喘, 可以有效的减少和预防支气管哮喘的发生。

Study on genetic correlation between infant asthma and bronchial asthma.

Objective To explore the mode of inheritance and genetic correlation was observed between the two of infant asthma and bronchial asthma, and provide a theoretical basis for the three grade prevention of asthma. Method Through the Falconer regression method to estimate the heritability of infant asthma and bronchial asthma, Logistic regression analysis of the major risk factors was summarized, S-N-K method were compared. Results The heritability for infants with asthma was (80.53±7.85)%, the heritability of bronchial asthma was (78.87±6.99)%.There was no significant difference between the two risk factors. Conclusion Genetic factors play a major role in the onset and development of asthma, other risk factors play a role, both have close correlation.Therefore, prevention of asthma in infants and young children can effectively reduce and prevent the occurrence of asthma.