| 大鼠大脑皮层葡萄糖代谢的缺氧习服适应性特点研究 |
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| 引用本文： | 黄缄,高钰琪,张国斌,曹利飞,孙秉庸.大鼠大脑皮层葡萄糖代谢的缺氧习服适应性特点研究[J].环境与健康杂志,2003,20(6):334-336. |
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| 作者姓名： | 黄缄 高钰琪 张国斌 曹利飞 孙秉庸 |
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| 作者单位： | 第三军医大学高原军事医学系病理生理学与高原生理学教研室,全军高原生理与高原病研究重点实验室,重庆,400038 |
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| 基金项目： | 国家自然科学基金资助项目(39730190) |
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| 摘 要： | 目的 分析脑组织中葡萄糖代谢的缺氧习服适应性特点。方法 将大鼠置模拟海拔5000m低压舱内，30d后取动脉血，测定血气、血糖等，取大脑皮层用葡萄糖氧化酶法测定葡萄糖、糖原含量，用酶法测定三磷酸腺苷(ATP）、磷酸肌酸、乳酸水平，并和对照组比较。结果 与对照组相比，缺氧组血糖、大脑皮层葡萄糖含量显著增加，而糖原显著降低，大脑皮层ATP、磷酸肌酸、乳酸在缺氧组与对照组之间差异无显著性。结论 经过缺氧习服适应后，组织能量代谢能达到平衡状态，葡萄糖利用加强。
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| 关 键 词： | 缺氧 能量代谢 习服 三磷酸腺苷 |
| 文章编号： | 1001-5914(2003)06-0334-03 |
| 修稿时间： | 2003年3月3日 |
Characteristics of Energy Metabolism in Rat Cerebral Cortex After Hypoxia Acclimatization |
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| HUANG Jian,GAO Yu-qi,ZHANG Guo-bin,et al..Characteristics of Energy Metabolism in Rat Cerebral Cortex After Hypoxia Acclimatization[J].Journal of Environment and Health,2003,20(6):334-336. |
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| Authors: | HUANG Jian GAO Yu-qi ZHANG Guo-bin |
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| Institution: | HUANG Jian,GAO Yu-qi,ZHANG Guo-bin,et al.Department of Pathophysiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing400038,China |
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| Abstract: | Objective To investigate the characteristics of energy metabolism in rat cortex after hypoxia acclimati-zation.Methods The artery blood gases,blood sugar were determined after exposing the rats to mimic altitude5000m hypobaric hypoxia environment for30days and the contents of glucose and glycogen in rat cerebral cortex were ana-lyzed by alyco-oxidase method,lactatic acid,ATP,phosphocreatine(PCr)in the rat cerebral cortex were also analysed.Results The contents of glucose in cerebral cortex and blood sugar were significantly increased in the hypoxic group compared with the control group,while the levels of glycogen were decreased.The contents of ATP,PCr,and lactatic acid showed no significant difference between the hypoxic group and the control group(P>0.05).Conclusion The en-ergy metabolism could retain stability after hypoxia acclimatization and the glucose utilization increase d. |
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| Keywords: | Anoxia Energy metabolism Acclimatization ATP |
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