代谢综合征与心脑血管病关系的前瞻性研究

目的探讨我国人群中代谢综合征(MS)与心脑血管疾病发生的关系。方法于1983-1984年在北京市和广州市35～59岁的男女性城市和农村人群中进行心脑血管病危险因素基线调查,并对研究对象进行随访至2005年底,登记并核实心脑血管病事件(包括冠心病事件和脑卒中事件)的发生情况及各种原因的死亡。根据中华医学会糖尿病分会推荐的标准确定基线时研究对象是否罹患MS。结果共纳入研究对象9 434人,其中男性4 621人,女性4 813人,男女性MS患病率分别为4.2%和5.2%。在平均19年的随访期间,研究对象共发生心脑血管病事件786例(男性488例,女性298例)。在调整多种危险因素后,男女性MS者发生心脑血管病事件、冠心病事件、总脑卒中事件和缺血性脑卒中事件的风险明显高于非MS者(P值均<0.05),MS者发生出血性脑卒中的相对危险也高于非MS者(男性:RR=1.48,95%CI:0.71～3.09,女性:RR=2.54,95%CI:1.15～5.60),但在男性中差异未达到显著性水平(P=0.297)。结论 MS者发生心脑血管病的风险明显增加,但MS与出血性脑卒中的关系值得进一步研究。

A prospective study on association of metabolic syndrome with cardiovascular disease

Objective To explore the association of metabolic syndrome （MS） with cardiovascular disease （CVD） among Chinese population. Methods Adult individuals aged 35-59 years both from urban and rural areas in Beijing and Guangzhou were surveyed for CVD risk factors from 1983-1984, and all subjects were followed up by the end of 2005, and CVD, CHD （acute myocardial infarction, CHD death and coronary sud- den death） and stroke event as well as the causes of death were all documented. MS was defined according to Chinese Diabetes Society standard. Results A total of 9434 individuals （4621of men and 4813 of women） were enrolled in the study. The incidence of MS at baseline was 4.2% for men and 5.2% for women, respec- tively. During an approximately 19 years follow-up period, 786 CVD events （488 in men and 298 in women） were recorded. Several other risk factors were adjusted, and subjects with MS had higher risk for attack of CVD, CHD, stroke and ischemic stroke （P〈0.05） . The significant higher risk of developing hemorrhagic stroke was also noticed for female subjects with MS （RR=2.54, 95% CI： 1.15-5.60）, but not for male （RR：I. 48, 95% CI： O. 71-3.09, P=0. 297）. Conclusions Metabolic syndrome is associated with an in creased risk of CVD, and more studies need to be done to verify the association between MS and hemorrhagic stroke.