CYP3A4和CYP2D6基因多态性与美沙酮维持治疗反应的关联研究

目的探讨CYP3A4和CYP2 D6基因多态性与海洛因成瘾者美沙酮维持治疗反应的关联性。方法随机选取6所美沙酮维持治疗门诊中进行维持治疗的海洛因成瘾者作为研究对象,收集研究对象的一般社会人口学特征,相关吸毒史和美沙酮维持治疗信息,并收集外周血测定CYP3A4和CYP2 D6多态位点的基因型。结果共纳入研究对象820例。其中,治疗反应好组210例,治疗反应差组610例。不同治疗反应组间治疗者的年龄比较,差异有统计学意义(P0.05)。CYP3A4 rs2242480和CYP2 D6 rs16947在治疗反应好组和治疗反应差组间的基因型频率分布和等位基因频率分布差异均无统计学意义(均P0.05)。结论尚未发现CYP3A4rs2242480和CYP2 D6 rs16947与治疗反应有关联。

Association between genetic polymorphism of CYP3A4, CYP2D6 and response to methadone maintenance treatment

ObjectiveTo explore the association between the genetic polymorphism of CYP3A4, CYP2D6 and response to methadone maintenance treatment(MMT) among heroin dependent patients. MethodsPatients undergoing MMT in 6 MMT clinics were randomly selected, information about general socia demographic characteristics, drug abuse history, and MMT data of patients were collected, genotypes of peripheral blood CYP3A4 and CYP2D6 polymorphic loci were detected. ResultsA total of 820 patients were enrolled in the study, 210 cases were with good response and 610 cases with poor response to MMT. Difference in age between different response groups was statistically significant(P＜0.05). Distribution of genotype frequency and allele frequency of CYP3A4 rs2242480 and CYP2D6 rs16947 between good response and poor response groups was not significantly different (both P>0.05). ConclusionThe association between CYP3A4 rs2242480, CYP2D6 rs16947 and response to MMT has not yet found in heroin dependent patients.