370株凝固酶阴性葡萄球菌临床分布及耐药性调查

目的了解某院凝固酶阴性葡萄球菌（CNS）临床分布及其耐药情况，指导临床合理使用抗菌药物。方法采用ATB Expresson细菌鉴定及药敏系统对2005年1月-2006年12月住院患者各类标本分离到的CNS进行鉴定和药敏试验。结果共分离到CNS 370株，以表皮葡萄球菌和溶血葡萄球菌为主。其耐药性以对青霉素、红霉素、苯唑西林耐药率最高，分别为92．98％、92．70％和84．05％；对克林霉素、第2代喹诺酮类药的耐药率次之，均〉70％；对夫西地酸、米诺环素、替考拉宁等耐药率均很低，对万古霉素无耐药性。结论CNS是医院感染的重要病原菌，耐药情况严峻，应对其进行严密监测，并规范使用抗菌药物，延缓其耐药性的产生。

Distribution and drug resistance of 370 strains of coagulase negative Staphylococcus isolated from a hospital

Objective To study the distribution and drug resistance of coagulase negative Staphylococcus(CNS)in a hospital,so as to provide the reference for the rational use of antimicrobial agents.Methods CNS isolated from inpatients from January,2005 to December,2006 were identified with ATB Expression microbial identification and drug sensitivity system.Results A total of 370 strains of CNS were isolated,most CNS were Staphylococcus epidermidis and Staphylococcus hemolyticus,the drug-resistant rate to penicillin,erythromycin and oxacillin was 92.98%,92.70% and 84.05% respectively,drug-resistant rates to clindamycin and second generation quinolones were both >70%,drug-resistant rates to fusidate,minocycline and teicoplanin were all low.The susceptible rate of CNS to vancomycin was 100%.Conclusion CNS is playing a significant role in nosocomial infection.The drug resistance of CNS is very serious,it is important to monitor the antimicriobial resistance of CNS.Clinical doctors should use antimicrobial agents rationally and slow down the producing of drug resistance.