某院重症医学科2010—2013年鲍曼不动杆菌耐药性监测

目的分析重症医学科2010—2013年鲍曼不动杆菌(AB)的检出率及耐药特征，为临床抗感染治疗提供依据。方法对某院重症医学科2010—2013年AB检出情况、耐药性进行回顾性分析。结果2010—2013年共分离病原菌1 413株，其中AB共556株，占39.35%，每年AB检出率分别是39.45%、41.35%、29.44%、40.53%。AB主要来源于下呼吸道(占75.72%)。药敏试验结果显示耐药率较低的抗菌药物是头孢哌酮/舒巴坦（5.85%）和阿米卡星（17.45%）；2010—2013年多重耐药、泛耐药AB检出率分别从9.63%、3.70%，上升至42.50%、31.88%，差异均有统计学意义（均P＜0.001）。结论AB是重症医学科最常见致病菌，对抗菌药物耐药严重，多重耐药、泛耐药AB检出率逐年增加；加强对AB的耐药性监测，有利于治疗和预防AB感染。

Monitoring of antimicrobial resistance of Acinetobacter baumannii in the intensive care unit of a hospital from 2010 to 2013

ObjectiveTo analyze the isolation rates and antimicrobial resistance of Acinetobacter baumannii(AB) from intensive care unit(ICU) between 2010 and 2013, and provide evidence for clinical anti infective therapy.MethodsThe isolation and antimicrobial resistance of AB from ICU between 2010 and 2013 were analyzed retrospectively.ResultsA total of 1 413 pathogenic strains were isolated, 556(39.35%) of which were AB, isolation rates in each year were 39.45%,41.35%,29.44%,and 40.53% respectively. AB were mainly isolated from lower respiratory tract (75.72%). Antimicrobial susceptibility testing results showed that AB had low resistance rates to cefoperazone/sulbactam（5.85%）and amikacin （17.45%）；detection rates of multidrug resistant and extensively drug resistant AB increased from 9.63% and 3.70% to 42.50% and 31.88%，respectively（both P＜0.001）.ConclusionAB is the common pathogen in ICU, antimicrobial resistance is serious, isolation of multidrug resistant and extensively drug resistant AB increased year by year； intensifying the monitoring of drug resistance is helpful for the treatment and prevention of AB infection.