抗菌药物对肠球菌属细菌体外抗菌活性

目的了解抗菌药物对某院临床分离肠球菌属细菌的体外抗菌活性。方法对2013年6月—2014年7月该院临床各科室送检标本分离的188株肠球菌属细菌进行细菌鉴定及药物敏感试验。结果 188株肠球菌属细菌其中屎肠球菌119株、粪肠球菌60株、鸟肠球菌9株,主要分布在尿和血标本,分别占34.57%和19.15%。未检出对达托霉素及利奈唑胺耐药的肠球菌属细菌;屎肠球菌对万古霉素的耐药率为1.68%,对青霉素、氨苄西林、高浓度庆大霉素、红霉素、左氧氟沙星的耐药率均70%;除四环素外,粪肠球对其他抗菌药物的耐药率均低于屎肠球菌,粪肠球对青霉素、氨苄西林耐药率较低,分别为16.67%,13.33%。结论达托霉素对该院肠球菌属细菌具有良好的抗菌效果。

In vitro activity of antimicrobial agents against Enterococcus spp.

ObjectiveTo investigate in vitro activity of antimicrobial agents against Enterococcus spp. isolated from clinic specimens in a hospital.Methods188 Enterococcus spp. isolates from specimens sent by clinic departments in June 2013 July 2014 were identified and performed antimicrobial susceptibility testing.ResultsOf 188 Enterococcus spp. isolates, 119 were Enterococcus faecium(E. faecium), 60 were E. faecalis, and 9 were E. avium, these strains were mainly isolated from urine (34.57%) and blood specimens(19.15% ). No daptomycin and linezolid resistant strain was detected;resistant rates of E. faecium to vancomycin was 1.68%, to penicillin，ampicillin，high concentration gentamycin，erythromycin,and levofloxacin were all ＞ 70%; except tetracycline, resistant rates of E.faecalis to the other antimicrobial agents were all lower than E. faecium, resistant rates of E. faecalis to penicillin and ampicillin were 16.67% and 13.33% respectively.ConclusionDaptomycin has high activity against Enterococcus spp. in this hospital.