青春期女生尿液中大豆异黄酮代谢物与性发育的关系

  目的  探讨尿液中大豆异黄酮代谢物与青春期女生性发育的关系, 为女生青春期发育影响因素研究提供参考依据。  方法  在信阳市1所小学随机选择符合纳入标准的50名五年级女生为研究对象, 进行性发育评价及尿液中大豆异黄酮代谢物的测定。尿液中大豆异黄酮代谢物的测定运用超高速液相色谱-串联质谱分析法(UPLC-MS/MS)。  结果  不同性发育组女生(发育提前、发育正常和发育延迟)的染料木黄酮水平差异有统计学意义(F=3.53, P < 0.05), 发育提前组尿液染料木黄酮水平较高; 已来潮组和未来潮组染料木黄酮水平差异有统计学意义(t=2.16, P < 0.05), 已来潮组尿液染料木黄酮水平较高。  结论  尿液染料木黄酮水平高可能与青春期女生性发育提前有关。

Relationship between soy isoflavone metabolites in urine and sexual development of adolescent girls

  Objective  To explore the relationship between urinary soybean isoflavone metabolites and sexual development of adolescent girls.  Methods  Fifty girls of grade 5 from one primary school in Xingang City who met the inclusion criteria were selected. Sexual characteristic development was assessed and soybean isoflavone metabolites in urine was tested by ultra-high speed liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).  Results  Levels of dye xylinone in girls with different stages of sexual development (advanced, normal, and delayed groups) varied significantly (F=3.53, P < 0.05), highest in advanced group. Urinary genistein was significantly higher in menarche group than that of non-menarche group (t=2.16, P < 0.05). Urinary genistein may be associated with early sexual development among adolescent girls.  Conclusion  High level of urine genistein may be related to the early sexual development of adolescent girls.