血红素加氧酶的生物学功能研究进展

血红素加氧酶（HO）是组成微粒体酶系统的重要组分之一,它能催化降解血红素生成胆红素、游离铁离子和一氧化碳。HO有3种同功酶,其中HO-1被认为具有细胞保护作用。血红素降解过程是一系列的自身催化的氧化反应过程,生成的3种产物在生理条件下对保持内环境稳态均有重要作用。

The biological function of heme oxygenase

One of the most important microsomal enzyme system is heme oxygenase(HO),which performs physiological catabolism of heme,yields bilirudin,iron and carbon monoxide,as final products.There are three isozymes for heme oxygenase,only HO-1 is considered to have the cytoprotective effects.Heme degradation process essentially is a series of autocatalytic oxidation reactions,all three products of this reaction are biologically active molecules which play important role in keeping tissue redox homeostasis under various pathophysiological conditions.