| 噪声作业人员听力防护认知与职业紧张关系研究 |
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| 引用本文： | 李晓亮,杨敏,何平,何东奎,廖锡庆,黄瑞妍.噪声作业人员听力防护认知与职业紧张关系研究[J].中国工业医学杂志,2021,34(3):202-206. |
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| 作者姓名： | 李晓亮 杨敏 何平 何东奎 廖锡庆 黄瑞妍 |
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| 作者单位： | 中国人民解放军总医院第五医学中心感染病医学部研究所 |
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| 基金项目： | 广东省科技计划项目(2014A020209052，2018A070701008)；广东省职业病防治重点实验室(2017B030314152) |
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| 摘 要： | 人源异种移植（patient-derived xenograft, PDX）模型是将取自临床患者的新鲜肿瘤标本直接异种移植到免疫缺陷小鼠体内而建立的动物模型，可以较好的保持原发肿瘤的组织形态、异质性以及基因异常等特征，并保留与患者相似的遗传特性。本文就人肝细胞癌PDX模型构建的实验动物、移植组织类型和方式的选择、最新应用进展以及PDX未来在肝细胞癌中的运用展望进行综述，以期为肝细胞癌的个性化治疗提供新的研究方向。
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| 关 键 词： | 肝细胞癌 PDX模型 研究进展 |
Association between hearing protection cognition and occupational stress of noise exposed workers |
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| LI Xiao-liang,YANG Min,HE Ping,HE Dong-kui,LIAO Xi-qing,HUANG Rui-yan.Association between hearing protection cognition and occupational stress of noise exposed workers[J].Chinese Journal of Industrial Medicine,2021,34(3):202-206. |
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| Authors: | LI Xiao-liang YANG Min HE Ping HE Dong-kui LIAO Xi-qing HUANG Rui-yan |
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| Abstract: | The patient-derived xenograft (PDX) model is established by transplanting fresh tumor specimen of clinical patients directly into immunodeficient mice. It can better maintain the histomorphology, heterogeneity and genetic abnormalities of primary tumors and reserve the genetic characteristics similar to those of patients. In order to provide a new research direction for individualized treatment of hepatocellular carcinoma, this study reviews the selection of the type and methods of experimental animals and transplanted tissues for PDX model of human hepatocellular carcinoma. The latest application progress and the future application prospect of PDX in hepatocellular carcinoma are reviewed. |
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| Keywords: | hepatocellular carcinoma PDX model research progress |
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